DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and Arntl

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_017444554.1	Gene:	Arntl / 29657	RGDID:	62003	Length:	633	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	215/411 - (52%)
Similarity:	295/411 - (71%)	Gaps:	17/411 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FCENMEEIEDENYDEEKSARTSD--ENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLD 68
            |.|:|:..:|:.:...:.|....  :|.::.||:||||||||||::|:||:|::|.|.||.||||
  Rat    53 FEESMDTDKDDPHGRLEYAEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLD 117

  Fly    69 KLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVS 133
            |||||||||||::.:|  |:.:|:..::|:|:||||.|||.:||:|::|||||||||||:||:||
  Rat   118 KLTVLRMAVQHMKTLR--GATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVS 180

  Fly   134 DSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCR 198
            :||..:||.:|.||:|||.||.||||||.||||||||.:..||||||||||.||||||:.....|
  Rat   181 ESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSR 245

  Fly   199 LCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIK 263
            ||.|||||||||||....| .:::::...|:.|:....|||..|       |..|||||||.|.|
  Rat   246 LCSGARRSFFCRMKCNRPS-VKVEDKDFASTCSKKKADRKSFCT-------IHSTGYLKSWPPTK 302

  Fly   264 -DEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQR 327
             ..|:|::.|.:..||||||||||:    .:..||..::....::.:.::|||:.:|||:|:|||
  Rat   303 MGLDEDSEPDNEGCNLSCLVAIGRL----HSHMVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQR 363

  Fly   328 ATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWR 392
            ||.::.:||||:||||.|||||.:||..|.|.|:.|:|..||:||..|:|:.||.|:|.|:|.|.
  Rat   364 ATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWF 428

  Fly   393 AFKNPWTSEIDYIIAKNSVFL 413
            :|.||||.|::||::.|:|.|
  Rat   429 SFMNPWTKEVEYIVSTNTVVL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	35/52 (67%)
		PAS	111..212	CDD:279347	72/100 (72%)
		PAS	111..173	CDD:214512	44/61 (72%)
		PAS_11	311..411	CDD:291273	54/99 (55%)
		PAS	311..406	CDD:238075	52/94 (55%)
Arntl	XP_017444554.1	bHLH-PAS_ARNTL_PASD3	74..137	CDD:381444	38/64 (59%)
		PAS	156..215	CDD:214512	40/58 (69%)
		PAS_11	346..448	CDD:405306	54/101 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4878
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H910
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1744
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm44650
orthoMCL	1	0.900	-	-		OOG6_106197
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.870