Protein Alignment cyc and Bmal2

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: XP_006507111.1
• Gene: Bmal2 / 272322
• MGIID: 2684845
• Length: 595
• Species: Mus musculus
• Alignment Length: 412
• Identity: 188/412 - (45%)
• Similarity: 260/412 - (63%)
• Gaps: 32/412 - (7%)

  Fly    10 MEEIEDENYDEEKSART---SDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLT 71
            :|.:....:....|.||   :....::.||::|||||||||..|.:||||||.......|||||:
Mouse    25 VESLPQNPFASLLSTRTGVSAPSGIREAHSQMEKRRRDKMNHLIQKLSSMIPPHIPTAHKLDKLS 89

  Fly    72 VLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSV 136
            |||.|||:||.:||...|  :.|.:.:|||:.|:||..:||:|:|||||||||:||||.|||.||
Mouse    90 VLRRAVQYLRSLRGMTEL--YLGENSKPSFIQDKELSHLILKAAEGFLFVVGCERGRIFYVSKSV 152

  Fly   137 SSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVK---TDVPQSLCR 198
            |..|...||.|:||:.||.|||||:.|||||| |.:..|||:.||.||.....   |..|    |
Mouse   153 SKTLRYDQASLIGQNLFDFLHPKDVAKVKEQL-SCDGSPREKPIDTKTSQVYSHPYTGRP----R 212

  Fly   199 LCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIK 263
            :..|:|||||.|||..|.   .:|||...||.|:....|        |:..:.|||||:|| |:.
Mouse   213 MHSGSRRSFFFRMKSCTV---PVKEEQPCSSCSKKKDHR--------KFHTVHCTGYLRSW-PLN 265

  Fly   264 --DEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQ 326
              ..::::...:.:..|:||||:||:.|.:    ||.. ....|:|...||:|.:..|||:::||
Mouse   266 VVGMEKESGGGKDSGPLTCLVAMGRLHPYI----VPQK-SGKINVRPAEFITRFAMNGKFVYVDQ 325

  Fly   327 RATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEW 391
            |||.::|:||||:||||.|||||.:|.::|.:.||.|:|..||:.|..|:||.||.:::.|:|||
Mouse   326 RATAILGYLPQELLGTSCYEYFHQDDHSSLTDKHKAVLQSKEKILTDSYKFRVKDGAFVTLKSEW 390

  Fly   392 RAFKNPWTSEIDYIIAKNSVFL 413
            .:|.||||.|::||::.|::.|
Mouse   391 FSFTNPWTKELEYIVSVNTLVL 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	34/60 (57%)
		PAS	111..173	CDD:214512	42/61 (69%)
		PAS_11	311..411	CDD:464214	52/99 (53%)
Bmal2	XP_006507111.1	bHLH_SF	49..108	CDD:469605	34/60 (57%)
		PAS	125..184	CDD:214512	39/58 (67%)
		PAS_11	309..411	CDD:464214	52/101 (51%)