DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyc and sim1a

DIOPT Version :10

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:NP_835740.2 Gene:sim1a / 260351 ZFINID:ZDB-GENE-020829-1 Length:745 Species:Danio rerio


Alignment Length:390 Identity:107/390 - (27%)
Similarity:178/390 - (45%) Gaps:70/390 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLR-------GIRGSGSL 89
            |:......:.||:|.|:...||:.::|:..|:..:|||.:::|:...:|:       |:..|.  
Zfish     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRIVFPEGLGESW-- 64

  Fly    90 HPFNGSDYRPSFLSD--QELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSW 152
                |...|.:.|.:  :||...:||..:||:|||..| |:|||:|::.|..|..:|.:|.|.|.
Zfish    65 ----GHVSRTTSLENVGRELGSHLLQTLDGFIFVVAPD-GKILYISETASVHLGLSQVELTGNSI 124

  Fly   153 FDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCRMKLRTAS 217
            ::.:||.|..::...|:: .|......:....|                  .||||.|||...| 
Zfish   125 YEYIHPADHDEMTAVLTA-HQPYHSHFVHEYEM------------------ERSFFLRMKCVLA- 169

  Fly   218 NNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLV 282
                              ||.:.||.| .|:||.|:||||    |:....|....:.......||
Zfish   170 ------------------KRNAGLTCG-GYKVIHCSGYLK----IRQYSLDMSPFDGCYQNVGLV 211

  Fly   283 AIGR-IPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYE 346
            |:|. :||     :....:..|.|    :|:.|.|.:.|.:|:|.|...:.|:.||:::..:.|.
Zfish   212 AVGHSLPP-----SAVTEIKLHSN----MFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYH 267

  Fly   347 YFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            :.|:.|...|..:|.::: |..:|||:.|||..|...::.:||......|..:|....|::.|.|
Zfish   268 HVHSCDTFHLRCAHHLLL-VKGQVTTKYYRFLAKQGGWVWVQSYATIVHNSRSSRPHCIVSVNYV 331

  Fly   412  411
            Zfish   332  331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 bHLH_SF 31..92 CDD:469605 16/66 (24%)
PAS 111..173 CDD:214512 23/61 (38%)
PAS_11 311..411 CDD:464214 29/99 (29%)
sim1aNP_835740.2 bHLH-PAS_SIM1 1..71 CDD:381581 18/74 (24%)
PAS 88..>158 CDD:238075 23/89 (26%)
PAS_3 243..329 CDD:430001 24/86 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..413
SIM_C 358..647 CDD:461963
Nuclear localization signal. /evidence=ECO:0000250 368..387
Blue background indicates that the domain is not in the aligned region.

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