Protein Alignment cyc and Arnt

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_036912.3
• Gene: Arnt / 25242
• RGDID: 2153
• Length: 809
• Species: Rattus norvegicus
• Alignment Length: 420
• Identity: 175/420 - (41%)
• Similarity: 259/420 - (61%)
• Gaps: 43/420 - (10%)

  Fly    14 EDENY--DEEKSARTSDEN--------RKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLD 68
            :||..  |:|:.||:.||.        .::||||||:|||:||..||.|||.|:|.|.|:.||.|
  Rat    63 DDEQMCNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPD 127

  Fly    69 KLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVS 133
            |||:|||||.|::.:||:|:... :|| |:||||:|||||.:||:|::||||:|.|:.||::|||
  Rat   128 KLTILRMAVSHMKSLRGTGNTST-DGS-YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVS 190

  Fly   134 DSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCR 198
            |||:.|||..|::..|.:.:|.:||.|:.|::||||:.|.....|::|.||. .||.:..||..|
  Rat   191 DSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMR 254

  Fly   199 LCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTG---------HKYRVIQCTG 254
            :|.|:||||.|||:..|:|       .|..|.:|.|..| :|...|         | :.|:.|||
  Rat   255 MCMGSRRSFICRMRCGTSS-------VDPVSMNRLSFLR-NRCRNGLGSVKEGEPH-FVVVHCTG 310

  Fly   255 YLKSWTP----IKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRH 315
            |:|:|.|    :.|:|.:|....:    .|||||||:  .|.:|  |...|.....:...|||||
  Rat   311 YIKAWPPAGVSLPDDDPEAGQGSK----FCLVAIGRL--QVTSS--PNCTDMSNICQPTEFISRH 367

  Fly   316 SGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCK 380
            :.||.|.|:|.|....:|:.|||:||.:..|:.|.||...|.:|.:.|:::..:|.:.::|||.|
  Rat   368 NIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRAK 432

  Fly   381 DNSYIQLQSEWRAFKNPWTSEIDYIIAKNS 410
            :..::.:::....|:||::.||:|||..|:
  Rat   433 NREWLWMRTSSFTFQNPYSDEIEYIICTNT 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	35/60 (58%)
		PAS	111..173	CDD:214512	31/61 (51%)
		PAS_11	311..411	CDD:464214	38/100 (38%)
Arnt	NP_036912.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..95		5/21 (24%)
		bHLH-PAS_ARNT	86..150	CDD:381517	35/63 (56%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P53762	88..128		22/39 (56%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762	112..264		79/154 (51%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762	112..168		33/57 (58%)
		PAS	163..269	CDD:395786	53/106 (50%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762	167..171		2/3 (67%)
		PAS_11	362..462	CDD:464214	37/99 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..685
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..809