DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyc and Sim1

DIOPT Version :10

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:XP_006512689.1 Gene:Sim1 / 20464 MGIID:98306 Length:801 Species:Mus musculus


Alignment Length:420 Identity:110/420 - (26%)
Similarity:181/420 - (43%) Gaps:94/420 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLR--------------- 81
            |:......:.||:|.|:...||:.::|:..|:..:|||.:::|:...:|:               
Mouse     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEVRCKFRMQ 66

  Fly    82 -------GIRGSGSLH----PFNGSDY-----------RPSFLSD--QELKMIILQASEGFLFVV 122
                   .:.|.|...    ..|.|||           |.|.|.:  :||...:||..:||:|||
Mouse    67 TPGFLRYSLMGPGISRRKETDSNNSDYLGLGEAWGHTSRTSPLDNVGRELGSHLLQTLDGFIFVV 131

  Fly   123 GCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLP 187
            ..| |:|:|:|::.|..|..:|.:|.|.|.::.:||.|..::...|::.:              |
Mouse   132 APD-GKIMYISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQ--------------P 181

  Fly   188 VKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC 252
            ..:...|..     ...||||.|||...|                   ||.:.||.| .|:||.|
Mouse   182 YHSHFVQEY-----EIERSFFLRMKCVLA-------------------KRNAGLTCG-GYKVIHC 221

  Fly   253 TGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGR-IPPNVRNSTVPASLDNHPNIRHVLFISRHS 316
            :||||    |:....|....:.......|||:|. :||     :....:..|.|    :|:.|.|
Mouse   222 SGYLK----IRQYSLDMSPFDGCYQNVGLVAVGHSLPP-----SAVTEIKLHSN----MFMFRAS 273

  Fly   317 GEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKD 381
            .:.|.:|:|.|...:.|:.||:::..:.|.:.|..|...|..:|.::: |..:|||:.|||..|.
Mouse   274 LDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLL-VKGQVTTKYYRFLAKQ 337

  Fly   382 NSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            ..::.:||......|..:|....|::.|.|
Mouse   338 GGWVWVQSYATIVHNSRSSRPHCIVSVNYV 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 bHLH_SF 31..92 CDD:469605 16/85 (19%)
PAS 111..173 CDD:214512 22/61 (36%)
PAS_11 311..411 CDD:464214 29/99 (29%)
Sim1XP_006512689.1 bHLH-PAS_SIM1 1..107 CDD:381581 21/104 (20%)
PAS 124..>194 CDD:238075 22/89 (25%)
PAS_3 279..365 CDD:430001 24/86 (28%)
SIM_C 395..704 CDD:461963
Blue background indicates that the domain is not in the aligned region.

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