Protein Alignment cyc and AHR

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_001612.1
• Gene: AHR / 196
• HGNCID: 348
• Length: 848
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 100/411 - (24%)
• Similarity: 175/411 - (42%)
• Gaps: 92/411 - (22%)

  Fly    29 ENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLR-------GIRGS 86
            |..|.|.|   ||.||::||.::.|:|::|....:..|||||:|||::|.:||       .::.|
Human    29 EGIKSNPS---KRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90

  Fly    87 -----GSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQAD 146
                 |.......:::|.. |:.||.: .:|||..||:.||..| ..:.|.|.::...|...|:|
Human    91 PTERNGGQDNCRAANFREG-LNLQEGE-FLLQALNGFVLVVTTD-ALVFYASSTIQDYLGFQQSD 152

  Fly   147 LLGQSWFDVLHPKDIGKVKEQLS---SLEQCPRERLIDAKTMLPVKTDVPQSLCRLC-------- 200
            ::.||.::::|.:|..:.:.||.   :..||     .::...:...|.:||::  :|
Human   153 VIHQSVYELIHTEDRAEFQRQLHWALNPSQC-----TESGQGIEEATGLPQTV--VCYNPDQIPP 210

  Fly   201 ---PGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPI 262
               |...|.|.||::...          |.||.                :..:...|.||.....
Human   211 ENSPLMERCFICRLRCLL----------DNSSG----------------FLAMNFQGKLKYLHGQ 249

  Fly   263 KDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNI-----RHVLFISRHSGEGKFL 322
            |.:.:|...               :||.:....:...| ..|:|     ::.:|.::|..:...:
Human   250 KKKGKDGSI---------------LPPQLALFAIATPL-QPPSILEIRTKNFIFRTKHKLDFTPI 298

  Fly   323 FIDQRATLVIGFLPQEILGT-SFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQ 386
            ..|.:..:|:|:...|:... |.|::.|..|:....|||..:::..|.... |:|...|:|.:..
Human   299 GCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMI-VFRLLTKNNRWTW 362

  Fly   387 LQSEWR-AFKNPWTSEIDYII 406
            :||..| .:||   ...||||
Human   363 VQSNARLLYKN---GRPDYII 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	25/72 (35%)
		PAS	111..173	CDD:214512	19/64 (30%)
		PAS_11	311..411	CDD:464214	27/98 (28%)
AHR	NP_001612.1	bHLH-PAS_AhR	28..88	CDD:381442	24/61 (39%)
		PAS	113..226	CDD:395786	32/121 (26%)
		PAS_3	297..382	CDD:430001	25/88 (28%)