DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cyc and Npas2

DIOPT Version :9

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:NP_032745.2 Gene:Npas2 / 18143 MGIID:109232 Length:816 Species:Mus musculus


Alignment Length:418 Identity:129/418 - (30%)
Similarity:195/418 - (46%) Gaps:90/418 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 DENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQH 79
            ||  ||:..|:.:..|:.      ||:|||:.|..|.|||||:|   ...||:||.|||...:  
Mouse     2 DE--DEKDRAKRASRNKS------EKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVI-- 53

  Fly    80 LRGIRGSGSLHPFN-----------GSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVS 133
                   |.|...|           ..|::|||||::|...::|:|.:||:.||..| |.|:|||
Mouse    54 -------GFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTD-GSIIYVS 110

  Fly   134 DSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCR 198
            ||::.:|....||::.|:..:.|..::..:|.:.|||      ..|:         ||.|.    
Mouse   111 DSITPLLGHLPADVMDQNLLNFLPEQEHSEVYKILSS------HMLV---------TDSPS---- 156

  Fly   199 LCPGARRS-----FFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKS 258
              |...:|     |:|.: ||.:.|   .:|..|                   |..|:..|..:|
Mouse   157 --PEFLKSDNDLEFYCHL-LRGSLN---PKEFPT-------------------YEYIKFVGNFRS 196

  Fly   259 WTPIKDEDQDADSDEQTTNLSCLVAIGR---IPPNVRNSTVPASLDNHPNIRHVL--FISRHSGE 318
            :..:  .....:..:.|.:..|.|.:|:   ....||.:| |..|.........|  |.||||.|
Mouse   197 YNNV--PSPSCNGFDNTLSRPCHVPLGKDVCFIATVRLAT-PQFLKEMCVADEPLEEFTSRHSLE 258

  Fly   319 GKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNS 383
            .||||:|.||..:||:||.|:||||.|:|:|.:|:..|...|:.:||. .|..:..|||..|...
Mouse   259 WKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQ 322

  Fly   384 YIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            :|.||:.:....:.|.|:.::|:..:||
Mouse   323 WIWLQTHYYITYHQWNSKPEFIVCTHSV 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 HLH 31..84 CDD:278439 20/52 (38%)
PAS 111..212 CDD:279347 31/105 (30%)
PAS 111..173 CDD:214512 23/61 (38%)
PAS_11 311..411 CDD:291273 41/99 (41%)
PAS 311..406 CDD:238075 40/94 (43%)
Npas2NP_032745.2 bHLH-PAS_NPAS2_PASD4 1..77 CDD:381580 30/94 (32%)
Sufficient for heterodimer formation with ARNTL/BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269|PubMed:23831463 1..61 28/78 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 8/26 (31%)
PAS 84..195 CDD:366402 40/155 (26%)
PAS_11 249..352 CDD:373151 43/103 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..431
omega_3_PfaA <440..>740 CDD:274311
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..639
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 685..705
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 742..816
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3561
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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