Protein Alignment cyc and Npas2

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_032745.2
• Gene: Npas2 / 18143
• MGIID: 109232
• Length: 816
• Species: Mus musculus
• Alignment Length: 418
• Identity: 129/418 - (30%)
• Similarity: 195/418 - (46%)
• Gaps: 90/418 - (21%)

  Fly    15 DENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQH 79
            ||  ||:..|:.:..|:.      ||:|||:.|..|.|||||:|   ...||:||.|||...:
Mouse     2 DE--DEKDRAKRASRNKS------EKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVI-- 53

  Fly    80 LRGIRGSGSLHPFN-----------GSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVS 133
                   |.|...|           ..|::|||||::|...::|:|.:||:.||..| |.|:|||
Mouse    54 -------GFLQKHNEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFVIVVTTD-GSIIYVS 110

  Fly   134 DSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCR 198
            ||::.:|....||::.|:..:.|..::..:|.:.|||      ..|:         ||.|.
Mouse   111 DSITPLLGHLPADVMDQNLLNFLPEQEHSEVYKILSS------HMLV---------TDSPS---- 156

  Fly   199 LCPGARRS-----FFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKS 258
              |...:|     |:|.: ||.:.|   .:|..|                   |..|:..|..:|
Mouse   157 --PEFLKSDNDLEFYCHL-LRGSLN---PKEFPT-------------------YEYIKFVGNFRS 196

  Fly   259 WTPIKDEDQDADSDEQTTNLSCLVAIGR---IPPNVRNSTVPASLDNHPNIRHVL--FISRHSGE 318
            :..:  .....:..:.|.:..|.|.:|:   ....||.:| |..|.........|  |.||||.|
Mouse   197 YNNV--PSPSCNGFDNTLSRPCHVPLGKDVCFIATVRLAT-PQFLKEMCVADEPLEEFTSRHSLE 258

  Fly   319 GKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNS 383
            .||||:|.||..:||:||.|:||||.|:|:|.:|:..|...|:.:||. .|..:..|||..|...
Mouse   259 WKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHLMQF-GKGKSCCYRFLTKGQQ 322

  Fly   384 YIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            :|.||:.:....:.|.|:.::|:..:||
Mouse   323 WIWLQTHYYITYHQWNSKPEFIVCTHSV 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	22/60 (37%)
		PAS	111..173	CDD:214512	23/61 (38%)
		PAS_11	311..411	CDD:464214	41/99 (41%)
Npas2	NP_032745.2	bHLH-PAS_NPAS2_PASD4	1..77	CDD:381580	30/94 (32%)
		Sufficient for heterodimer formation with BMAL1, E-box binding and for the effect of NADPH. /evidence=ECO:0000269|PubMed:23831463	1..61		28/78 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		8/26 (31%)
		PAS	84..195	CDD:395786	40/155 (26%)
		PAS_11	249..352	CDD:464214	43/103 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..431
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	610..639
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..705
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..816