DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and Ncoa1

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_006515068.1	Gene:	Ncoa1 / 17977	MGIID:	1276523	Length:	1447	Species:	Mus musculus

Alignment Length:	409	Identity:	92/409 - (22%)
Similarity:	161/409 - (39%)	Gaps:	108/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DEEKSARTSDENRKQNH------SEIEKRRRDKMNTYINELSSMIPMCF----AMQRKLDKLTVL 73
            |........|.::::..      |..|||||::.|.|:.||:.::....    ::..|.||..:|
Mouse     6 DSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKIL 70

  Fly    74 RMAVQHLRGIRGSGSLHPFNGSDYRPSFLSD--------QELKMIILQASEGFLFVVGCDRGRIL 130
            :..|..::.::...........|.:.|.:|.        :.|..::|:|.:||.|||.|: |||:
Mouse    71 KKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIV 134

  Fly   131 YVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQS 195
            :||::|:|.|...|.:|:..|.:.:||..|..:.                       ||..:|:|
Mouse   135 FVSENVTSYLGYNQEELMNTSVYSILHVGDHAEF-----------------------VKNLLPKS 176

  Fly   196 LCRLCP----GARR---SFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC- 252
            |....|    ..||   :|.|||        .|....|..:.::.:.:|         |.|:||
Mouse   177 LVNGVPWPQEATRRNSHTFNCRM--------LIHPPEDPGTENQEACQR---------YEVMQCF 224

  Fly   253 -TGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHV-LFISRH 315
             ....||   |:::.:|..        |||:.|.|            .|...|.|..| .|:::.
Mouse   225 TVSQPKS---IQEDGEDFQ--------SCLICIAR------------RLPRPPAITGVESFMTKQ 266

  Fly   316 SGEGKFLFIDQ---RATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQ---- 373
            ...||.:.||.   ||....|:  ::::....|.:|..:.     .......|:.::|.|:
Mouse   267 DTTGKIISIDTSSLRAAGRTGW--EDLVRKCIYAFFQPQG-----REPSYARQLFQEVMTRGTAS 324

  Fly   374 --VYRFRCKDNSYIQLQSE 390
              .|||...|.:.:...::
Mouse   325 SPSYRFILNDGTMLSAHTK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	15/62 (24%)
		PAS	111..212	CDD:279347	33/107 (31%)
		PAS	111..173	CDD:214512	22/61 (36%)
		PAS_11	311..411	CDD:291273	17/89 (19%)
		PAS	311..406	CDD:238075	17/89 (19%)
Ncoa1	XP_006515068.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	15/59 (25%)
		PAS	120..213	CDD:238075	34/124 (27%)
		PAS_11	260..370	CDD:405306	17/91 (19%)
		NCOA_u2	469..591	CDD:406952
		SRC-1	636..712	CDD:400955
		DUF4927	747..824	CDD:406644
		Nuc_rec_co-act	930..975	CDD:400942
		Med15	980..>1366	CDD:312941
		DUF1518	1155..1211	CDD:400033
		DUF1518	1218..1274	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810