DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and Arnt

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001032826.1	Gene:	Arnt / 11863	MGIID:	88071	Length:	791	Species:	Mus musculus

Alignment Length:	413	Identity:	173/413 - (41%)
Similarity:	255/413 - (61%)	Gaps:	41/413 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DEEKSARTSDEN--------RKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRM 75
            |:|:.||:.||.        .::||||||:|||:||..||.|||.|:|.|.|:.||.||||:|||
Mouse    70 DKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRM 134

  Fly    76 AVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVL 140
            ||.|::.:||:|:... :|| |:||||:|||||.:||:|::||||:|.|:.||::||||||:.||
Mouse   135 AVSHMKSLRGTGNTST-DGS-YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVL 197

  Fly   141 NSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARR 205
            |..|::..|.:.:|.:||.|:.|::||||:.|.....|::|.||. .||.:..||..|:|.|:||
Mouse   198 NQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRVLDLKTG-TVKKEGQQSSMRMCMGSRR 261

  Fly   206 SFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTG---------HKYRVIQCTGYLKSWTP 261
            ||.|||:..|:|       .|..|.:|.|..| :|...|         | :.|:.||||:|:|.|
Mouse   262 SFICRMRCGTSS-------VDPVSMNRLSFLR-NRCRNGLGSVKEGEPH-FVVVHCTGYIKAWPP 317

  Fly   262 ----IKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFL 322
                :.|:|.:|....:    .|||||||:  .|.:|  |...|.....:...|||||:.||.|.
Mouse   318 AGVSLPDDDPEAGQGSK----FCLVAIGRL--QVTSS--PNCTDMSNICQPTEFISRHNIEGIFT 374

  Fly   323 FIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQL 387
            |:|.|....:|:.|||:||.:..|:.|.||...|.:|.:.|:::..:|.:.::|||.|...::.:
Mouse   375 FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWLWM 439

  Fly   388 QSEWRAFKNPWTSEIDYIIAKNS 410
            ::....|:||::.||:|||..|:
Mouse   440 RTSSFTFQNPYSDEIEYIICTNT 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	32/52 (62%)
		PAS	111..212	CDD:279347	49/100 (49%)
		PAS	111..173	CDD:214512	31/61 (51%)
		PAS_11	311..411	CDD:291273	38/100 (38%)
		PAS	311..406	CDD:238075	35/94 (37%)
Arnt	NP_001032826.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..97		7/23 (30%)
		DNA-binding. /evidence=ECO:0000269\|PubMed:26245371, ECO:0000269\|PubMed:28602820	88..128		22/39 (56%)
		HLH	91..143	CDD:278439	32/51 (63%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000269\|PubMed:26245371	112..264		79/154 (51%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000269\|PubMed:26245371	112..168		33/57 (58%)
		PAS	163..269	CDD:279347	53/106 (50%)
		PAS	166..230	CDD:214512	31/63 (49%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000269\|PubMed:24001774	167..171		2/3 (67%)
		PAS_11	362..462	CDD:291273	37/99 (37%)
		PAS	362..458	CDD:238075	35/95 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..508
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..554
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..667
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..715
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810