Protein Alignment cyc and Ahr

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_038492.1
• Gene: Ahr / 11622
• MGIID: 105043
• Length: 805
• Species: Mus musculus
• Alignment Length: 407
• Identity: 97/407 - (23%)
• Similarity: 169/407 - (41%)
• Gaps: 87/407 - (21%)

  Fly    29 ENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRG------IRGSG 87
            |..|.|.|   ||.||::||.::.|:|::|....:..|||||:|||::|.:||.      ...|.
Mouse    28 EGIKSNPS---KRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKST 89

  Fly    88 SLHPFNGSDYRPSFLSD-QELK--MIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLG 149
            ......|.|...:.:.| |:|:  ..:|||..||:.||..| ..:.|.|.::...|...|:|::.
Mouse    90 PADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTAD-ALVFYASSTIQDYLGFQQSDVIH 153

  Fly   150 QSWFDVLHPKDIGKVKEQL---------SSLEQC---PRERLIDAKTMLPVKTDVPQSLCRLCPG 202
            ||.::::|.:|..:.:.||         ..:::.   |:..:......||     |::...:
Mouse   154 QSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLP-----PENASFM--- 210

  Fly   203 ARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQ 267
             .|.|.||::...          |.||.                :..:...|.||.......:.:
Mouse   211 -ERCFRCRLRCLL----------DNSSG----------------FLAMNFQGRLKYLHGQNKKGK 248

  Fly   268 DADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNI-----RHVLFISRHSGEGKFLFIDQR 327
            |.               ..:||.:....:...| ..|:|     ::.:|.::|..:...:..|.:
Mouse   249 DG---------------ALLPPQLALFAIATPL-QPPSILEIRTKNFIFRTKHKLDFTPIGCDAK 297

  Fly   328 ATLVIGFLPQEILGT-SFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEW 391
            ..|::|:...|:... |.|::.|..||....|||..:::..|...| |:|...|.:.:..:||..
Mouse   298 GQLILGYTEVELCTRGSGYQFIHAADILHCAESHIRMIKTGESGMT-VFRLLAKHSRWRWVQSNA 361

  Fly   392 R-AFKNPWTSEIDYIIA 407
            | .::|   ...|||||
Mouse   362 RLIYRN---GRPDYIIA 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	24/66 (36%)
		PAS	111..173	CDD:214512	19/70 (27%)
		PAS_11	311..411	CDD:464214	28/99 (28%)
Ahr	NP_038492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		5/12 (42%)
		Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869	12..15
		bHLH-PAS_AhR	27..87	CDD:381442	24/61 (39%)
		Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869	36..41		3/4 (75%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869	37..65		10/27 (37%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869	49..81		14/31 (45%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869	63..71		6/7 (86%)
		PAS	111..>177	CDD:395786	19/66 (29%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	116..124		4/7 (57%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	260..262		0/1 (0%)
		PAS_3	291..376	CDD:430001	26/89 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..449