DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and npas4l

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001316841.1	Gene:	npas4l / 108449885	ZFINID:	ZDB-GENE-070117-2515	Length:	647	Species:	Danio rerio

Alignment Length:	397	Identity:	93/397 - (23%)
Similarity:	143/397 - (36%)	Gaps:	123/397 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 KRRRDKMNTYINELSSMIPMCFAMQRKLDKL-------TVLRMAVQHLRGI-RGSGSLHPFNGSD 96
            |.|||:||:.|..|.:::|:  :.:.:|..|       |.:|.:|: |||: ..|......||..
Zfish    26 KARRDQMNSEIRNLRALLPI--SPEHRLSYLHSMSITCTYIRKSVE-LRGVCEESTVFSAVNGCV 87

  Fly    97 YRPSFLSD-------------QE--LKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQAD 146
            .:...|.|             ||  |:..:|||..||:.....| |::||||::|...|..:..|
Zfish    88 PQDCALQDCALQECVLQECVLQECVLQECVLQALPGFIVAFTTD-GKLLYVSENVHEYLGLSMVD 151

  Fly   147 LL-GQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCR 210
            :| ..|:||:|...|:..|           |..|.||.                 |...|...||
Zfish   152 VLQSDSFFDMLDRSDVEAV-----------RSVLADAS-----------------PSGERWVVCR 188

  Fly   211 MKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQT 275
            |.:..|..                                     |:|
Zfish   189 MLVSKAMR-------------------------------------LRS----------------- 199

  Fly   276 TNLSC---LVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQ 337
               ||   ||.| |:...|..|....:.|..| .|:..|.:.||.:.:...........:||...
Zfish   200 ---SCCPLLVRI-RLRDGVCVSLCRPTADRLP-ARNADFHTHHSADMRLASASSSVLFHLGFSAD 259

  Fly   338 EILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEI 402
            |::|.|:||..|.:|:....:.|..::.........:.|.:|||.|::.:.:...|     |:|.
Zfish   260 ELIGRSWYELLHPDDLRHAADRHAAILAAATADAEMLIRVQCKDLSWVWMYTHASA-----TAER 319

  Fly   403 DYIIAKN 409
            |.|...|
Zfish   320 DAISCSN 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	17/51 (33%)
		PAS	111..212	CDD:279347	29/101 (29%)
		PAS	111..173	CDD:214512	21/62 (34%)
		PAS_11	311..411	CDD:291273	24/99 (24%)
		PAS	311..406	CDD:238075	22/94 (23%)
npas4l	NP_001316841.1	Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	16..29		1/2 (50%)
npas4l	NP_001316841.1	Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	30..67		10/38 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910