DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyc and bmal1

DIOPT Version :10

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:XP_031756277.1 Gene:bmal1 / 100422809 XenbaseID:XB-GENE-495455 Length:628 Species:Xenopus tropicalis


Alignment Length:407 Identity:215/407 - (52%)
Similarity:292/407 - (71%) Gaps:15/407 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 FCENMEEIEDENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKL 70
            |.|.|:..:|:.::..........|.::.||:||||||||||::|:||:|::|.|.||.||||||
 Frog    53 FDEGMDTEKDDPHELLDFTEGRLRNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKL 117

  Fly    71 TVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDS 135
            |||||||||::.:||:.  :|:..::|:|:||||.|||.:||:|::|||||||||||:||:||:|
 Frog   118 TVLRMAVQHMKTLRGAA--NPYTEANYKPAFLSDDELKQLILRAADGFLFVVGCDRGKILFVSES 180

  Fly   136 VSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLC 200
            |..:||.:|.||:|||.||.||||||.||||||||.:..||||||||||.||||||:.....|||
 Frog   181 VFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 245

  Fly   201 PGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIK-D 264
            .|||||||||||....| .:::::...|:.|:....|||..|       |..|||||||.|.| .
 Frog   246 SGARRSFFCRMKCNRPS-VKVEDKDFPSNCSKKKADRKSFCT-------IHSTGYLKSWPPTKMG 302

  Fly   265 EDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRAT 329
            .|:|.:.|.:..||||||||||:.|::    ||...:....::...::|||:.:|||:|:|||||
 Frog   303 LDEDNEPDNEGCNLSCLVAIGRLHPHI----VPQPANGEIRVKSTEYVSRHAIDGKFVFVDQRAT 363

  Fly   330 LVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAF 394
            .::|:||||:||||.|||||::||..|.:.||.|:|..||:||..|:|:.||.|:|.|:|.|.:|
 Frog   364 AILGYLPQELLGTSCYEYFHHDDIGHLADCHKQVLQTREKITTNCYKFKIKDGSFITLKSRWFSF 428

  Fly   395 KNPWTSEIDYIIAKNSV 411
            .||||.|::||::.|:|
 Frog   429 MNPWTKEVEYIVSTNTV 445

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 bHLH_SF 31..92 CDD:469605 37/60 (62%)
PAS 111..173 CDD:214512 44/61 (72%)
PAS_11 311..411 CDD:464214 55/99 (56%)
bmal1XP_031756277.1 bHLH-PAS_ARNTL_PASD3 72..135 CDD:381444 38/64 (59%)
PAS 154..213 CDD:214512 40/58 (69%)
PAS_11 344..447 CDD:464214 56/102 (55%)

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