DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and arntl2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001096298.1	Gene:	arntl2 / 100124875	XenbaseID:	XB-GENE-6454872	Length:	594	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	195/409 - (47%)
Similarity:	264/409 - (64%)	Gaps:	28/409 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EFCENMEEIEDENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDK 69
            ||....:..:.:|...|.| ..:|...::.|.|.|||||:|||..|..||:|||....:..|.||
Frog    48 EFPRKRKASDSDNQVTEGS-DVNDTQGREAHRETEKRRREKMNNLIENLSAMIPQSGPLPSKPDK 111

  Fly    70 LTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSD 134
            |||||||||||:.::||..  .|.....:||||..:|:|.:||:|::|||||:|||||.||:||:
Frog   112 LTVLRMAVQHLKSLKGSNP--SFADESPKPSFLKHEEMKQLILRAADGFLFVIGCDRGEILFVSE 174

  Fly   135 SVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRL 199
            ||:..|...|.||:|:|.||.|||||:.||||||||.:..|||:||||||.|.|.|....|  ||
Frog   175 SVTKTLKYNQGDLMGKSLFDFLHPKDVAKVKEQLSSSDIAPREKLIDAKTGLQVHTHFQAS--RL 237

  Fly   200 CPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKD 264
            ..|:|||||||||...|::   |||.|...:|    |||..    .:|..|.|||||:|..|
Frog   238 HWGSRRSFFCRMKSGRANH---KEEKDFLRNS----KRKDH----RRYCTIHCTGYLRSCPP--- 288

  Fly   265 EDQDADSDEQTTNLSCLVAIGRIPPNV--RNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQR 327
            .:::.|:|.:..|..|||||||:.|.:  :||       :...::...|::|::.:|||:::|||
Frog   289 SEEECDTDREAPNSRCLVAIGRLHPYITPQNS-------SEVKVKPTEFVTRYTMDGKFVYVDQR 346

  Fly   328 ATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWR 392
            ||.::|:||||:||||.|||||.:|...|.:.||.|:|..|||.|..|:||.||.|:|.|||:|.
Frog   347 ATAILGYLPQELLGTSCYEYFHIDDYGHLTDRHKAVLQSSEKVETNCYKFRVKDGSFITLQSQWF 411

  Fly   393 AFKNPWTSEIDYIIAKNSV 411
            .|.||||.:::||::.|:|
Frog   412 GFINPWTKDLEYIVSVNTV 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	30/52 (58%)
		PAS	111..212	CDD:279347	63/100 (63%)
		PAS	111..173	CDD:214512	40/61 (66%)
		PAS_11	311..411	CDD:291273	53/99 (54%)
		PAS	311..406	CDD:238075	51/94 (54%)
arntl2	NP_001096298.1	bHLH_SF	73..132	CDD:381792	32/60 (53%)
		PAS	155..243	CDD:238075	53/89 (60%)
		PAS_11	329..434	CDD:373151	54/102 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1720
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm47694
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060