DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2ad6

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001076405.1	Gene:	cyp2ad6 / 799957	ZFINID:	ZDB-GENE-041001-157	Length:	492	Species:	Danio rerio

Alignment Length:	508	Identity:	152/508 - (29%)
Similarity:	251/508 - (49%)	Gaps:	50/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHI--LFERWAKDFR 67
            :||...|:  ::..||.: :.|.||||||..:|.|||..      :.|..:.:  |.|::...|
Zfish    16 LFLTCFLL--LLIDLIRN-KNPANFPPGPWPLPILGNVF------TDVNYKTVDQLIEKYGNIF- 70

  Fly    68 SDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHR 130
                .:::|.:.:|...|.:|||:|.:.  |.|..||.:..  ..|:...:|::..:|..|.:|:
Zfish    71 ----SVRIGSDKIVYVSGFKMVKDVLITQGENFTDRPVSPL--FDTLYKGRGLSFNNGYSWRKHQ 129

  Fly   131 HFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIAR 195
            .|:|..::|.|.||..:|.:.:.|...|.|..:..:.:|.:|:..:..:|.||:..|:.|.|...
Zfish   130 QFSMSHLKNFGEGRKTLEENNQRECYFLCGAFKEEQGRPFDPLVKINNAVANVIGFLVFGHRYEY 194

  Fly   196 QEDGTLRRLLDLMNRRS---------KLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGF 251
            .:....:||  .|:..|         :|:|...|::...|     .|.:|..:..|    :|..|
Zfish   195 SDVNFQKRL--QMSAESVFLTGSVWNQLYDAFPGIMKWVP-----GPHQTIISNYQ----KLANF 248

  Fly   252 FMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTS 315
            ..:.||:|:... ..:|    .|.|.|||.|.:.:....|:. |....||.:::|.|..|::||:
Zfish   249 LEEKIEQHKPDWDISNP----RDYIDAYLTEAEKKKNDTEAG-FTVGSLVWSMVDLFEGGTETTT 308

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            ||:..||:.|...||:|:|:.:::...:.:    ..|.:|.:....|::|||.||.|..::.|:.
Zfish   309 NTLRWALLFLIKYPDIQKKVQAEIDEVIGS----RLPSMSDKANMHYLNAFIHEVLRRANLVPLN 369

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            ..|.|...|.||||.|.|...::.:|.||..||:.|:.|..|.|:.|:||.|...:...|..|..
Zfish   370 MARVAKKDTTLGGYFITKGTVMITNLTSVLYDKQEWETPDAFNPKHFLDSEGHFCRRNAFFAFSA 434

  Fly   446 GRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKV 498
            |:|:|.|:.||...:|.||..::|.||...|.||.||:....|.|..|.|||:
Zfish   435 GKRQCPGEYLAHLELFIFLTILLQTFSFSPPDGEEPSLDSQVGFTQAPLPYKI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	144/483 (30%)
cyp2ad6	NP_001076405.1	p450	38..488	CDD:278495	144/483 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68091
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.010