Protein Alignment Cyp305a1 and cyp21a2

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_021330030.1
• Gene: cyp21a2 / 793249
• ZFINID: ZDB-GENE-070103-6
• Length: 522
• Species: Danio rerio
• Alignment Length: 538
• Identity: 137/538 - (25%)
• Similarity: 235/538 - (43%)
• Gaps: 80/538 - (14%)

  Fly    10 ILIGFVIYSLISSARRPKN----------------FP------------------PGPRFVPWLG 40
            :|:.|:::.|:...||..:                ||                  .|||.:|.||
Zfish     9 VLLLFILWMLVVKFRRQSHRRTDGVAKENNKPEAVFPKLLHSLYKLFFSTVSPTISGPRSLPLLG 73

  Fly    41 NTLQFRKEASAVGGQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPD 103
            |.|...::...:   |:  ...||.: .::..|..|...:||....|:::|  |:....|.|||.
Zfish    74 NMLDLAQDHLPI---HL--TALAKCY-GNIYRLNCGSTTMVVLNNSEIIREALVKKWSDFAGRPH 132

  Fly   104 NFFLRLRTMGTRKGITCTD-GQLWYEHR---HFAMKQMRNVGYGRSQMEHHIELEAEELLGQLER 164
            ::...:.:.|.|. |:..| .:.|..||   |.|:::...     ..:...||.:|:.|...|..
Zfish   133 SYTGDIVSRGGRT-ISLGDFSEEWKAHRRVTHSALQRCTT-----DSLHSVIEKQAQHLCQVLRD 191

  Fly   165 TEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICG----GLLAQF 225
            ...:.::.......:..||:..|...|...: ....|::|.:.:|   ::..:.|    ..|..|
Zfish   192 YSGKAVDLSEDFTVASSNVITTLTFSKAYDK-SSAELQKLQECLN---EIVSLWGSPWISALDSF 252

  Fly   226 PWLRHVAPDRTGYNLIQQL--NTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAG 288
            |.||.. |:.....|::::  ..||.|   ..|||.::...|:.....|.|    |:.::.:...
Zfish   253 PLLRKF-PNPPFSRLMKEVARRDELIG---KHIEEFKKSEHKEGGTLTSSL----LKCLEPQQGA 309

  Fly   289 GESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPH 353
            ...:|..:|.:.||.:|..|.|::|.:..:|..:..|..||:||:|::.::...:..    ..|.
Zfish   310 ANHTTLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCMLDV----RHPQ 370

  Fly   354 LSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKD 418
            .|.|....|:.|.|.|:.|...:.|:..|.||:..:.:.|:.||||..|:.:|...|.|.|.|.|
Zfish   371 YSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNLYGAHHDPEVWDD 435

  Fly   419 PLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSM 483
            |..|:||||::..|...:.  .:|||.|.|.|||:|:|:..:|.|...:::.|. .|||.:...:
Zfish   436 PYSFKPERFLEGGGGSLRS--LIPFGGGARLCLGEAVAKMEMFLFTAYLLREFK-FLPASKEEPL 497

  Fly   484 VLLPG---ITLTPKPYKV 498
            ..|.|   :.|..|||.|
Zfish   498 PELRGVASVVLKVKPYTV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	118/444 (27%)
cyp21a2	XP_021330030.1	cytochrome_P450	94..516	CDD:477761	119/448 (27%)