DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and si:dkey-286h2.3

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001073322.1	Gene:	si:dkey-286h2.3 / 790965	ZFINID:	ZDB-GENE-161014-2	Length:	496	Species:	Danio rerio

Alignment Length:	525	Identity:	168/525 - (32%)
Similarity:	260/525 - (49%)	Gaps:	60/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHIL----FER 61
            ::||:.||  |..|::| |....|||:||||||..||..||.||.         .||.    .::
Zfish     2 LTALVLLC--LGAFLLY-LQLRIRRPRNFPPGPAPVPIFGNLLQL---------NHINPIKDLDK 54

  Fly    62 WAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQE--VFEGRPDNFFLRLRTMGTRKGITCTD-G 123
            :|:.:.| :.|:.:|.:..||..|.:|:||..:.:  .|.||.:...:...|..  ||:...| |
Zfish    55 FAQHYGS-IYGIYIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVSHVTRS--KGVIMADYG 116

  Fly   124 QLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLI 188
            :.|.|||.||:..:||.|.|:..||..|..|.:.:...||.:..:||:|.....|:..|::..:|
Zfish   117 ESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAGKPIDPQHLYHQAASNIIASII 181

  Fly   189 AGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPW--LRHVA--------PDRTGYNLIQQ 243
            ...|...| |...:.|:..|.:.:|        :|..||  |..:|        |....:...:|
Zfish   182 FRSRFDYQ-DEYFQTLITTMEKLTK--------IAIGPWAMLYEIAPVLRIFPLPFHKAFQYFEQ 237

  Fly   244 LNTELYGFFMDTIEEHR-RQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFF 307
            :...:    :..:|||: .::|.:|    .|||..||:||..||  .:.:||:|:|:|..:.|.|
Zfish   238 ITNHV----LKVVEEHKTSRVAGEP----RDLIDCYLEEMNRRS--DKHTTFDESQMVTLLFDLF 292

  Fly   308 IAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLS--RREAFDYMDAFIMEV 370
            |||::|||||:....:.|.....:||:...::...:.|..     |::  .|.|..::.|.|.|.
Zfish   293 IAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARD-----HVTYEDRNAMHFVQAVIHEG 352

  Fly   371 QRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCF 435
            ||...|.|::....|...|:|.||.|||...|:..|.|...::..||.|.||.|:.|::..|:..
Zfish   353 QRVADIVPLSMFHTARTDTQLRGYSIPKGTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFV 417

  Fly   436 KDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPA-GESPSMVLLPGITLTPKPYKVQ 499
            |::.||||..|.|.|||:.|||..:|..||.:::.|.:|.|. .|.|....:.|.|.:.|||.:.
Zfish   418 KNDAFMPFSAGPRVCLGENLARMELFLILVTVLRKFRLVWPKDAEEPDFTYIYGGTQSLKPYPMI 482

  Fly   500 FVKRT 504
            ...||
Zfish   483 VKLRT 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	153/490 (31%)
si:dkey-286h2.3	NP_001073322.1	p450	28..485	CDD:278495	153/492 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000