DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2x9

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001070921.1	Gene:	cyp2x9 / 768288	ZFINID:	ZDB-GENE-061027-109	Length:	491	Species:	Danio rerio

Alignment Length:	517	Identity:	161/517 - (31%)
Similarity:	250/517 - (48%)	Gaps:	53/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFR-----KEASAVGGQHILFERWAKD 65
            ||..:.|..|:..|.....||||||||||.:|..||.|:..     |:          |||.|..
Zfish     4 FLILVWICIVLLFLFIQIPRPKNFPPGPRPLPLFGNLLELNINNPLKD----------FERLANR 58

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKEVQLQEV--FEGRPDNFFLRLRTMGTRKGITCTD-GQLWY 127
            : .::..|..|.:..||..|.|.:||..:.:.  |.|||.:..:...|.|  .|:..:| |..|.
Zfish    59 Y-GNIYSLYFGSKPWVVLNGFEALKEALVTKAVDFAGRPQDLMVNRVTKG--GGVILSDYGPSWK 120

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |||.||:..:||.|.|:..||..|..|...::.:||:......:|.|....:..|::..::.|.|
Zfish   121 EHRRFALMTLRNFGLGKQSMEERILGEVSHIIDKLEKRVGTAFDPQTMFHNAASNIICIVLFGSR 185

  Fly   193 IARQEDGTLRRLLDLMNRRSKLFDICGGLLAQ----FPWLRHV-APDRTGY---NLIQQLNTELY 249
            . ..:|..|:..:.|....:|   |..|..|.    ||..|:: .|.|..:   :..::|:|:|
Zfish   186 Y-DYDDEFLKLFIHLYTENAK---IANGPWAMIYDTFPMFRYLPLPFRKAFANASKARELSTQL- 245

  Fly   250 GFFMDTIEEHRRQLAKDPSPAE-SDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQT 313
                  ::||::...    |.| .|.|..||.|:..|  |.:.|:|:|.||::.:||...||:.|
Zfish   246 ------VKEHKKTWV----PGEPRDFIDCYLDELDKR--GNDGSSFSEAQLILYVLDLHFAGTDT 298

  Fly   314 TSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITP 378
            ||||:....:.|...|:||.|...::...:......::   ..|.:..|..|...||||..:..|
Zfish   299 TSNTLLTGFLYLMTHPEVQAKCQQEIDDVLEDKDQASY---EDRHSMPYTQAVTHEVQRVANTVP 360

  Fly   379 ITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPF 443
            ::........|:|.||:|||...::.:|.|...::..||.|.||.|..|::..|:..|.|.|:||
Zfish   361 LSVFHCTTKDTELMGYNIPKGTFVIPNLGSALKEEGQWKFPHEFNPANFLNEQGEFEKPEAFVPF 425

  Fly   444 GMGRRRCLGDALARACIFSFLVRIVQHFSVVLP--AGESPSMVLLPGITLTPKPYKVQFVKR 503
            ..|.|.|||:.|||..:|..:|.:::.|..|.|  ||: |....:.|:||||:||::...:|
Zfish   426 SAGPRVCLGEGLARMELFLVMVTLLRRFQFVWPNDAGK-PDYTPVYGVTLTPQPYRMHIKRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	150/488 (31%)
cyp2x9	NP_001070921.1	p450	28..479	CDD:278495	148/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3475
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950