DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c66

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001011707.1	Gene:	Cyp2c66 / 69888	MGIID:	1917138	Length:	490	Species:	Mus musculus

Alignment Length:	519	Identity:	144/519 - (27%)
Similarity:	242/519 - (46%)	Gaps:	57/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQF-RKEASAVGGQHILFERWAKDFR- 67
            :||..:|...::.||.....:.:|.||||..:|.:||.||. .|:.|             |..|
Mouse     5 VFLGLLLTCLLLLSLWKQNSQRRNLPPGPTPLPIIGNILQLDLKDIS-------------KSLRN 56

  Fly    68 -SDLVG----LKLGREYVVVALGHEMVKEVQLQ--EVFEGR-----PDNFFLRLRTMGTRKGITC 120
             |.:.|    |.||::..||..|::.|||..:.  |.|.||     .|.|..|.       |:..
Mouse    57 FSKVYGPVFTLYLGKKPAVVLHGYKAVKEALIDHGEEFAGRGTFPVADKFIRRC-------GVVF 114

  Fly   121 TDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLW 185
            :.|:.|.|.|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||:
Mouse   115 SSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTKGVPCDPTFILGCAPCNVI- 178

  Fly   186 CLIAGKRIARQEDGTLRRLLDLMNRR-----SKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLN 245
            |.|..:.....:|......:|::|..     |....:|.    .||.:....|.| ...|::..:
Mouse   179 CSIVFQNRFDYKDQEFLTFIDILNENVEILSSPWIQVCN----NFPAIIDYLPGR-HRKLLKNFD 238

  Fly   246 TELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIA 309
            ...: :|:..:.:|:..| ..:|    .|.|..:|.:| ::......:.|....|:.|..|.|.|
Mouse   239 FAKH-YFLAKVIQHKESLDINNP----RDFIDCFLIKM-EQEKHNPKTEFTCENLIFTASDLFAA 297

  Fly   310 GSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFF 374
            |::|||.|:..:|::|...|:|..|:.:::...:....:   |.:..|.:..|.||.:.|:||:.
Mouse   298 GTETTSTTLRYSLLLLLKYPEVTAKVQAEIDCVIGRHRS---PCMQDRHSMPYTDAVLHEIQRYI 359

  Fly   375 HITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEY 439
            .:.|.:.|.......|...|.|||..|::.||.||..|.:.:.:|..|.|..|:|.:||..|.:|
Mouse   360 DLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFLNPERFDPSHFLDESGKFKKSDY 424

  Fly   440 FMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAG--ESPSMVLLPGITLTPKPYKVQFV 501
            |.||..|:|.|:|:.|||..:|.||..|:|:|::..|..  :..:..:..|....|..:::.|:
Mouse   425 FFPFSTGKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFVSVPPKFQICFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	137/491 (28%)
Cyp2c66	NP_001011707.1	p450	30..487	CDD:278495	137/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920