Protein Alignment Cyp305a1 and Cyp2c66

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001011707.1
• Gene: Cyp2c66 / 69888
• MGIID: 1917138
• Length: 490
• Species: Mus musculus
• Alignment Length: 519
• Identity: 144/519 - (27%)
• Similarity: 242/519 - (46%)
• Gaps: 57/519 - (10%)

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQF-RKEASAVGGQHILFERWAKDFR- 67
            :||..:|...::.||.....:.:|.||||..:|.:||.||. .|:.|             |..|
Mouse     5 VFLGLLLTCLLLLSLWKQNSQRRNLPPGPTPLPIIGNILQLDLKDIS-------------KSLRN 56

  Fly    68 -SDLVG----LKLGREYVVVALGHEMVKEVQLQ--EVFEGR-----PDNFFLRLRTMGTRKGITC 120
             |.:.|    |.||::..||..|::.|||..:.  |.|.||     .|.|..|.       |:..
Mouse    57 FSKVYGPVFTLYLGKKPAVVLHGYKAVKEALIDHGEEFAGRGTFPVADKFIRRC-------GVVF 114

  Fly   121 TDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLW 185
            :.|:.|.|.|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||:
Mouse   115 SSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTKGVPCDPTFILGCAPCNVI- 178

  Fly   186 CLIAGKRIARQEDGTLRRLLDLMNRR-----SKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLN 245
            |.|..:.....:|......:|::|..     |....:|.    .||.:....|.| ...|::..:
Mouse   179 CSIVFQNRFDYKDQEFLTFIDILNENVEILSSPWIQVCN----NFPAIIDYLPGR-HRKLLKNFD 238

  Fly   246 TELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIA 309
            ...: :|:..:.:|:..| ..:|    .|.|..:|.:| ::......:.|....|:.|..|.|.|
Mouse   239 FAKH-YFLAKVIQHKESLDINNP----RDFIDCFLIKM-EQEKHNPKTEFTCENLIFTASDLFAA 297

  Fly   310 GSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFF 374
            |::|||.|:..:|::|...|:|..|:.:::...:....:   |.:..|.:..|.||.:.|:||:.
Mouse   298 GTETTSTTLRYSLLLLLKYPEVTAKVQAEIDCVIGRHRS---PCMQDRHSMPYTDAVLHEIQRYI 359

  Fly   375 HITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEY 439
            .:.|.:.|.......|...|.|||..|::.||.||..|.:.:.:|..|.|..|:|.:||..|.:|
Mouse   360 DLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFLNPERFDPSHFLDESGKFKKSDY 424

  Fly   440 FMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAG--ESPSMVLLPGITLTPKPYKVQFV 501
            |.||..|:|.|:|:.|||..:|.||..|:|:|::..|..  :..:..:..|....|..:::.|:
Mouse   425 FFPFSTGKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFVSVPPKFQICFI 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	124/448 (28%)
Cyp2c66	NP_001011707.1	CYP2C-like	61..485	CDD:410758	123/445 (28%)