DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2j8

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001098397.1	Gene:	Cyp2j8 / 665095	MGIID:	2449817	Length:	503	Species:	Mus musculus

Alignment Length:	518	Identity:	153/518 - (29%)
Similarity:	258/518 - (49%)	Gaps:	52/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            ::||..|  :|:.::      ..|.|||:||||..:|::||..||..:.|.:   |:..:.:.|.
Mouse    23 LAALTLL--LLVDYI------KNRHPKNYPPGPWRLPFVGNLFQFDLDVSHL---HLGIQPFVKK 76

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKEVQ--LQEVFEGRPDNFFLRLRT-MGTRKGITCTDGQLWY 127
            : .:|:.|..|....|:..|..::||..  :.:.|..||   .|..|. :....||..:.||.|.
Mouse    77 Y-GNLISLDFGTIPSVIISGEPLIKEALTCMGQNFLKRP---ILAARQHIFKNNGIISSSGQTWK 137

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |.|.|.:..::|.|.|:..:|..|:.||..|:..:...:.:|.:|...:..:|.|::..:..|:|
Mouse   138 EQRRFTLMILKNFGLGKKSLEQRIQDEAHHLVEAIAEEKGRPFDPHFMINNAVSNIICSITIGER 202

  Fly   193 IARQEDGTLRRLLDLMN-----RRSK---LFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            . ..||...:.||.|.:     ..||   |:::...:....|     .|.:..::..::|..
Mouse   203 F-EYEDNQFQELLKLADETLCLEASKVLMLYNVFPSIFKYLP-----GPHQKLFSNWEKLKL--- 258

  Fly   250 GFFMDTIEEHRRQLAKDPSP-AESDLIYAYLQEM---KDRSAGGESSTFNETQLVMTILDFFIAG 310
             ||...::.||    ||.:| |..|.|.|:|.||   .|::    :::|||..|:.|.||.|.||
Mouse   259 -FFSHVMDSHR----KDWNPSAPRDFIDAFLTEMAKYSDKT----TTSFNEENLICTTLDLFFAG 314

  Fly   311 SQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFH 375
            ::|||..:..||:.:.:.|:||||:.|::...:...   ..|.:..|::..|.:|.|.||.|..:
Mouse   315 TETTSTALRWALLYITVNPEVQEKVHSEIDRVIGQG---RHPTIDDRDSMPYTNAVIHEVLRMGN 376

  Fly   376 ITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYF 440
            |.|:..||.......|.|:.:||...:|.:|.::|.|.:.|..|..|.||.|::: |:..|.|.|
Mouse   377 IIPLNVPREVEADITLAGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLEN-GQFKKRESF 440

  Fly   441 MPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKR 503
            :||.:|:|.|.|:.|||:.:|:|...::|.|:...|..|..|:....|:.|:|..|.:..|.|
Mouse   441 LPFSVGKRGCPGEQLARSELFTFFTALMQKFTFKPPINEKLSLNFKMGVALSPVSYCICAVPR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	143/484 (30%)
Cyp2j8	NP_001098397.1	p450	44..499	CDD:365848	143/483 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920