Protein Alignment Cyp305a1 and Cyp2j8

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001098397.1
• Gene: Cyp2j8 / 665095
• MGIID: 2449817
• Length: 503
• Species: Mus musculus
• Alignment Length: 518
• Identity: 153/518 - (29%)
• Similarity: 258/518 - (49%)
• Gaps: 52/518 - (10%)

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            ::||..|  :|:.::      ..|.|||:||||..:|::||..||..:.|.:   |:..:.:.|.
Mouse    23 LAALTLL--LLVDYI------KNRHPKNYPPGPWRLPFVGNLFQFDLDVSHL---HLGIQPFVKK 76

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKEVQ--LQEVFEGRPDNFFLRLRT-MGTRKGITCTDGQLWY 127
            : .:|:.|..|....|:..|..::||..  :.:.|..||   .|..|. :....||..:.||.|.
Mouse    77 Y-GNLISLDFGTIPSVIISGEPLIKEALTCMGQNFLKRP---ILAARQHIFKNNGIISSSGQTWK 137

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |.|.|.:..::|.|.|:..:|..|:.||..|:..:...:.:|.:|...:..:|.|::..:..|:|
Mouse   138 EQRRFTLMILKNFGLGKKSLEQRIQDEAHHLVEAIAEEKGRPFDPHFMINNAVSNIICSITIGER 202

  Fly   193 IARQEDGTLRRLLDLMN-----RRSK---LFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            . ..||...:.||.|.:     ..||   |:::...:....|     .|.:..::..::|..
Mouse   203 F-EYEDNQFQELLKLADETLCLEASKVLMLYNVFPSIFKYLP-----GPHQKLFSNWEKLKL--- 258

  Fly   250 GFFMDTIEEHRRQLAKDPSP-AESDLIYAYLQEM---KDRSAGGESSTFNETQLVMTILDFFIAG 310
             ||...::.||    ||.:| |..|.|.|:|.||   .|::    :::|||..|:.|.||.|.||
Mouse   259 -FFSHVMDSHR----KDWNPSAPRDFIDAFLTEMAKYSDKT----TTSFNEENLICTTLDLFFAG 314

  Fly   311 SQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFH 375
            ::|||..:..||:.:.:.|:||||:.|::...:...   ..|.:..|::..|.:|.|.||.|..:
Mouse   315 TETTSTALRWALLYITVNPEVQEKVHSEIDRVIGQG---RHPTIDDRDSMPYTNAVIHEVLRMGN 376

  Fly   376 ITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYF 440
            |.|:..||.......|.|:.:||...:|.:|.::|.|.:.|..|..|.||.|::: |:..|.|.|
Mouse   377 IIPLNVPREVEADITLAGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLEN-GQFKKRESF 440

  Fly   441 MPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKR 503
            :||.:|:|.|.|:.|||:.:|:|...::|.|:...|..|..|:....|:.|:|..|.:..|.|
Mouse   441 LPFSVGKRGCPGEQLARSELFTFFTALMQKFTFKPPINEKLSLNFKMGVALSPVSYCICAVPR 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	131/444 (30%)
Cyp2j8	NP_001098397.1	cytochrome_P450	77..498	CDD:477761	131/446 (29%)