DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2aa1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001020728.2	Gene:	cyp2aa1 / 572000	ZFINID:	ZDB-GENE-070424-33	Length:	498	Species:	Danio rerio

Alignment Length:	499	Identity:	157/499 - (31%)
Similarity:	245/499 - (49%)	Gaps:	34/499 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRS 68
            |||    |:.|.|:.:.|...|   |||||..:|::||...|.|..       :.|.|:...: .
Zfish    21 LIF----LVLFEIFRIHSYKGR---FPPGPTPLPFVGNLPHFLKSP-------MEFIRFMPQY-G 70

  Fly    69 DLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRKGIT-CTDGQLWYEHRHF 132
            ::..:..||:.|::....::.||..:|:||.|||........|.|.  ||. .|....|.:.|.|
Zfish    71 EMTTIFFGRKPVIMLNTIQLAKEAYVQDVFSGRPAIPLFDWITNGL--GIVMVTFNNSWRQQRRF 133

  Fly   133 AMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQE 197
            |:..:||.|.|:..:|..:..|:..|:.::.:.|.:.:.|...|..::.|::..::.|.|. ..:
Zfish   134 ALHTLRNFGLGKKTVEDRVLEESRYLIAEMLKEEGKSMNPQHALQNAISNIICSIVFGDRF-EYD 197

  Fly   198 DGTLRRLLDLMNRRSKLFDICGGLLAQF-PWLRHV-APDRTGYNLIQQLNTELYGFFMDTIEEHR 260
            :.....||..:|....|.....|.:... |:::|. .|    :..|:|...||.||..|..:|||
Zfish   198 NKRFEYLLKTLNENIMLAGSAAGQIFNLVPFIKHFPGP----HQKIKQNADELLGFIRDEAKEHR 258

  Fly   261 RQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVL 325
            :.|..| ||  .|.|.|||.|: ::....:.|||:|..||::..|.|:||:.||..||...|:.|
Zfish   259 QTLDPD-SP--RDFIDAYLLEI-EKQKSSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINL 319

  Fly   326 AMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATK 390
            ...|||||:...::   |.....|..|.:..|:...|..|.:.|:||..:|.| ....:.:..||
Zfish   320 IQNPDVQERCHEEI---VRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAP-NVMHQTILPTK 380

  Fly   391 LGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDAL 455
            |.||:||:...||.:|.::..:|||||.|..|.||.|:|..|...|.|.|:||.:|.|.|||:.|
Zfish   381 LHGYNIPQGTIILTNLAAIFSNKEHWKHPDAFNPENFLDENGHFSKPESFIPFSLGPRVCLGETL 445

  Fly   456 ARACIFSFLVRIVQHFSVVLPAGESP-SMVLLPGITLTPKPYKV 498
            ||..:|.|:..::|......|....| .|..:.|:..:|:.:.|
Zfish   446 ARTELFLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	148/473 (31%)
cyp2aa1	NP_001020728.2	p450	40..487	CDD:278495	147/469 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920