DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2k8

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001124095.1	Gene:	cyp2k8 / 561462	ZFINID:	ZDB-GENE-080721-19	Length:	507	Species:	Danio rerio

Alignment Length:	521	Identity:	147/521 - (28%)
Similarity:	244/521 - (46%)	Gaps:	57/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGN--TLQFRKEASAVGGQHILFERWAKDFR 67
            :.|.|:|:..|:|.:..|:..|:: ||||:.:|.|||  ||..:       ..|:.....:|.:
Zfish    16 VLLSAVLLFLVVYLISISSSSPED-PPGPKPLPLLGNLHTLDLK-------NLHVSLWELSKKY- 71

  Fly    68 SDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRHF 132
            ..:..:.|||:.|||..|::.||:..:.:..|....:.....:.....:||...:|:.|...|.|
Zfish    72 GPVFKVHLGRKKVVVLAGYKTVKQALVNQAEEFGERDITPIFQDCNQGQGIVFANGERWRTMRRF 136

  Fly   133 AMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQE 197
            |:..:|:.|.|:...|..|..|...|.....:.|.||.:....:..:|.|::..::.|||. ..|
Zfish   137 ALSTLRDFGMGKKLSEEKIVDETRYLREVFMKFEGQPFDTTQPVNYAVSNIISAIVYGKRF-EYE 200

  Fly   198 DGTLRRLLDLMNRRSKLFDICGGLLAQF--------PWLRHVAPDRTGYNLIQQLNTELYGFFMD 254
            |...:   |::|:.:....:.|..:.|.        ||::          ..:||        |.
Zfish   201 DPAFQ---DMVNKANMNIRMIGSAVIQIYNMCPFLGPWIK----------TWRQL--------MK 244

  Fly   255 TIEEHRRQ-------LAKDPSPAE-SDLIYAYL-QEMKDRSAGGESSTFNETQLVMTILDFFIAG 310
            .:|..|||       |.:..:|.: ..||.::| ::...:..|.:.|:||:..|::|:.:.|.||
Zfish   245 NMESTRRQIQTLADVLQETLNPLDCRGLIDSFLIRKQNIQETGEKDSSFNDQNLLITVSNLFAAG 309

  Fly   311 SQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFH 375
            :.||..|:...||::|..|.:|:::..::...:....    |....|:...|.||.|.|.||..:
Zfish   310 TDTTGTTLRWGLMLMAKYPQIQDRVQEEIDQVLGGRE----PVAEDRKNLPYTDAVIHETQRLAN 370

  Fly   376 ITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYF 440
            |.|:..|.:........||.|.|...:|..|.||..|:..|:.|..|.|:.|:|..|:..|.:.|
Zfish   371 ILPLNLPHKTSCDVTFNGYFIKKGTCVLPLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAF 435

  Fly   441 MPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGES-PSMVLLP--GITLTPKPYKVQFVK 502
            |||..|||.|||::|||..:|.|...::|:|....|.|.| ..:.|.|  |:||.|.|:|:..|.
Zfish   436 MPFSAGRRACLGESLARMELFLFFTSLLQYFRFSPPPGASEDELDLTPVVGLTLNPSPHKLCAVI 500

  Fly   503 R 503
            |
Zfish   501 R 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	138/491 (28%)
cyp2k8	NP_001124095.1	p450	58..497	CDD:278495	128/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010