DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2u1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001139036.1	Gene:	cyp2u1 / 556280	ZFINID:	ZDB-GENE-070730-1	Length:	533	Species:	Danio rerio

Alignment Length:	536	Identity:	159/536 - (29%)
Similarity:	257/536 - (47%)	Gaps:	61/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLCAILIGFVIYSLISSARRP-------KNFPPGPRFVPW-------------------LGNTL 43
            :|..|.:.|.:.:.|:....:.       .|.||||:  ||                   :.|:.
Zfish    12 VFSPANIAGLIAFVLVFYVLQEYQWHQTYANIPPGPK--PWPIVGNFGGFLVPPFILKRFVKNSK 74

  Fly    44 QFRKEAS-AVGGQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNF 105
            :|.|..| .:..|..|.|  ......::..:.:|.:.:||..|::.|::..|.  |.|..||
Zfish    75 EFAKVVSNPLSPQAGLIE--MSKLYGNIFSIFVGPQLMVVLTGYDAVRDAMLNHTETFSDRP--- 134

  Fly   106 FLRLRTMGT-RKGITCTD-GQLWYEHRHFAMKQMRNVGYGRSQME---HH-IELEAEELLGQLER 164
            .:.|.|:.| ||||.... |.||..:|.|....:|:.|:||..:|   |. :.:...||...:|.
Zfish   135 HIPLVTIITKRKGIVFAPYGPLWRTNRRFCHSTLRSFGFGRMSLEPCIHEGLAIIKTELQSLIET 199

  Fly   165 TEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQ-FPWL 228
            .....|:....::.:|.|::..:..|:|. ..||...|.:.|||:...::......||.. ||||
Zfish   200 AGPSGIDLTPLISNAVSNIISLMSLGQRF-HHEDKEFRNMRDLMSHGLEISVNTSILLVNVFPWL 263

  Fly   229 RHVAPDRTGYNLIQQL---NTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEM--KDRSAG 288
            .::.     :.:.::|   ..::..|....|..||..|  ||.... |.|..||.||  |.:...
Zfish   264 YYLP-----FGVFKELRRAELDITAFLKRIIARHRATL--DPENPR-DFIDMYLVEMLAKQKEGS 320

  Fly   289 GESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPH 353
            .|.:.|:|..|...|.|.||||:.||:|::..:::.:::.||||||:..::.|.|   .::..|.
Zfish   321 SEENLFSEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQEKVQKEIDAVV---GSERVPS 382

  Fly   354 LSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKD 418
            |:.:.:..|.:|.||||.|...:.|::.|..|...|:..|:.|||...|:.:|.|||.|...|::
Zfish   383 LTDKSSLPYTEATIMEVIRMTVVVPLSIPHMASETTEFRGFTIPKGTVIIPNLWSVHRDPTVWEN 447

  Fly   419 PLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAG-ESPS 482
            |.:|.|.||:|..||..:.:.|:|||:|||.|:|:.||:..:|.....::|.|:...|.| .:||
Zfish   448 PDDFNPSRFLDDQGKILRKDCFIPFGLGRRVCMGEQLAKMELFLMFTSLMQTFTFRFPEGATAPS 512

  Fly   483 MVLLPGITLTPKPYKV 498
            |....|:||.|.|:.|
Zfish   513 MHGRFGLTLAPCPFTV 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	154/504 (31%)
cyp2u1	NP_001139036.1	p450	44..530	CDD:278495	154/504 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920