DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2f4

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062176.1	Gene:	Cyp2f4 / 54246	RGDID:	2476	Length:	491	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	165/530 - (31%)
Similarity:	251/530 - (47%)	Gaps:	79/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHIL--FERWA 63
            :|..|.|  :|:..:..||..::......||||:.:|.|||.||.|       .|.:|  ..:.:
  Rat     4 VSTAILL--LLLAVISLSLTFTSWGKGQLPPGPKPLPILGNLLQLR-------SQDLLTSLTKLS 59

  Fly    64 KDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPD-----NFFLRLRTMGTRKGITCT 121
            ||:.| :..:.||...|:|..|::.|||  |...|.|.||..     ||     |.|  .||..:
  Rat    60 KDYGS-VFTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGSYPIFFNF-----TKG--NGIAFS 116

  Fly   122 DGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWC 186
            ||:.|...|.|:::.:||.|.|:..:|..|..|...||..|.:||.:|.:||..|::||.|::..
  Rat   117 DGERWKILRRFSVQILRNFGMGKRSIEERILEEGSFLLDVLRKTEGKPFDPVFILSRSVSNIICS 181

  Fly   187 LIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTG--YNLIQQLNTEL- 248
            :|.|.|....::    |||.:::..:..|.|...     ||         |  ||:...|...:
  Rat   182 VIFGSRFDYDDE----RLLTIIHFINDNFQIMSS-----PW---------GEMYNIFPSLLDWVP 228

  Fly   249 ---------YGFFMD----TIEEHRRQLAKDPSPAESDLIYAYL----QEMKDRSAGGESSTFNE 296
                     :|...|    ::.||:..|  ||: :..|.|..:|    ||.:|     ..|.||.
  Rat   229 GPHRRVFRNFGGMKDLIARSVREHQDSL--DPN-SPRDFIDCFLTKMVQEKQD-----PLSHFNM 285

  Fly   297 TQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFD 361
            ..|:||..:....|::|...|:..|.::|...|.||.::..::...|..:   ..|.|..|.:..
  Rat   286 DTLLMTTHNLLFGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVVGRS---RMPTLEDRASMP 347

  Fly   362 YMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPER 426
            |.||.|.|||||..:.|:..|.|.:..|...|:.|||...::..|.:||.|.:.:|.|.||.||.
  Rat   348 YTDAVIHEVQRFADVIPMNLPHRVIRDTPFRGFLIPKGTDVITLLNTVHYDSDQFKTPQEFNPEH 412

  Fly   427 FIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLP---G 488
            |:|:.....|...||||..|||.|||:.|||..:|.:|..|:|:|: :.|..|...:.|.|   |
  Rat   413 FLDANQSFKKSPAFMPFSAGRRLCLGEPLARMELFIYLTSILQNFT-LHPLVEPEDIDLTPLSSG 476

  Fly   489 ITLTPKPYKV 498
            :...|:|:::
  Rat   477 LGNLPRPFQL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	159/501 (32%)
Cyp2f4	NP_062176.1	p450	31..488	CDD:278495	159/501 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920