DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2j16

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_578474.1	Gene:	Cyp2j16 / 502969	RGDID:	1561242	Length:	503	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	153/522 - (29%)
Similarity:	261/522 - (50%)	Gaps:	52/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SALIF--LCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAK 64
            ||:.|  |...|:.|::.:.....|||.|:||||..:|::||..||....|.:   |:..:::.|
  Rat    14 SAINFWTLLLTLLTFLLLADYLKNRRPNNYPPGPWRLPFVGNLFQFDLNISHL---HLRIQQFVK 75

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTR------KGITCTDG 123
            .: .:|:.|..|...|||..|..::||..:..      :..||:...:.:|      .||...:.
  Rat    76 KY-GNLISLDFGNISVVVITGLPLIKEALINN------EQNFLKRPIVPSRYRVFKDNGIFFANV 133

  Fly   124 QLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLI 188
            ..|.|.|.||:..::|.|.|:..:|..|:.||..|:..:...:.||.:|...:..:|.|::..:.
  Rat   134 HKWKEQRRFALTMLKNFGLGKKSLEQCIQEEAHHLVEVIGEEKGQPFDPHFRINNAVSNIICSIT 198

  Fly   189 AGKRIARQEDGTLRRLLDLMNR--------RSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLN 245
            .|:|. ..:|...:.||.|.:.        .|.|:::...:....|     .|.:|.:...::|.
  Rat   199 FGERF-EYDDSQFQELLKLADEVICSEASMTSVLYNVFPLIFKYLP-----GPHQTVFKNWEKLK 257

  Fly   246 TELYGFFMDTIEEHRRQLAKDPSPAE-SDLIYAYLQEM---KDRSAGGESSTFNETQLVMTILDF 306
            :    ...:.|:.||    ||.:|.| .|.:.|:|.||   .|::    :::|||..|:.|.||.
  Rat   258 S----IVANMIDRHR----KDWNPDEPRDFVDAFLTEMTKYPDKT----TTSFNEENLIATTLDL 310

  Fly   307 FIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQ 371
            |.||::|||.|:..||:.:.:.|:||||:.|::...:...   ..|....::|..|.:|.|.||.
  Rat   311 FFAGTETTSTTLRWALLYITLNPEVQEKVHSEIDRVIGHG---RLPSTDDQDAMPYTNAVIHEVL 372

  Fly   372 RFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK 436
            |..:|.|:..||.....:.|.|:.:||...||.:|.::|.|.:.|..|..|.||.|::: |:..|
  Rat   373 RMGNIIPLNVPREVTADSTLAGFHLPKGKMILTNLTALHRDPKEWATPDTFNPEHFLEN-GQFKK 436

  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFV 501
            .:.|:||.:|:|.|.|:.||::.:|.|...::|:|:...|..|..|:.|..|::|.|..|::..|
  Rat   437 RDSFLPFSVGKRACPGEKLAKSELFIFFTALMQNFTFKAPTNEKLSLKLRKGLSLYPVSYRICAV 501

  Fly   502 KR 503
            .|
  Rat   502 PR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	141/487 (29%)
Cyp2j16	XP_578474.1	p450	44..499	CDD:278495	141/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920