DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2v1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001009890.1	Gene:	cyp2v1 / 494153	ZFINID:	ZDB-GENE-040912-139	Length:	504	Species:	Danio rerio

Alignment Length:	508	Identity:	155/508 - (30%)
Similarity:	250/508 - (49%)	Gaps:	38/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILIGFVIYSLIS----SARRP-KNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSD 69
            ||:.|:::.|:|    :..:| ||.||||..:|::||.  |..:.|.   .||...:.: |...:
Zfish    21 ILLLFILFLLVSVKLRNRNKPHKNLPPGPTPLPFIGNV--FNLDTSQ---PHIDLTKMS-DHYGN 79

  Fly    70 LVGLKLGREYVVVALGHEMVKEVQLQE--VFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRHF 132
            :..|:||....||...:.|||:|...:  .|..||.|..  ...:...:|:|..:|..|.:||.|
Zfish    80 IFSLRLGSLNTVVVNTYSMVKKVLNDQGNSFMYRPVNDI--TERISKCQGLTFNNGYSWKQHRRF 142

  Fly   133 AMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQE 197
            .:..::..|.|:..:|..|..|.:.|...:..|...|..|...:...|.|::..::.|:|. ...
Zfish   143 TLSTLKFFGVGKRSLEFIIMEEYKFLHQSIMDTNGLPFNPHYIINNGVSNIICSMVFGRRF-EYT 206

  Fly   198 DGTLRRLLDLMNRRSKL-FDICGGLLAQFPWLRHV--APDRTGYNLIQQLNTELYGFFMDTIEEH 259
            |.....:|.|:::..|| ..:...|.|.||.|..:  .|.:..::...|:.    .|..:.:::|
Zfish   207 DQRFLNMLSLISKALKLQTSVFIQLYAAFPRLMDLLPGPHKELFSCFHQVR----AFIKEEVDKH 267

  Fly   260 RRQLAKDPSPAESDLIYAYLQEMK----DRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINL 320
            |...  ||| :..|.|..||.|::    |..||     |::..|...:||.|:||::|||.|:..
Zfish   268 RADW--DPS-SPRDFIDCYLTEIEKKKDDLEAG-----FHDEGLQYAVLDLFVAGTETTSTTLLW 324

  Fly   321 ALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRA 385
            |.:.:...|::|||:.:::...|.....   |.:..|....|.||.|.|:||..::.|::.||..
Zfish   325 AFVYMMKYPEIQEKVQAEIDKVVGRYRR---PSMDDRPCMPYTDAVIHEIQRMGNVVPLSVPRMT 386

  Fly   386 LWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRC 450
            ...|.|.||.|||...|:.:|.||..|:..||....|.|:.|:::.||..|.|.|:||.:|:|.|
Zfish   387 NEDTILEGYFIPKGTQIIPNLTSVLFDQTKWKTQHSFDPQNFLNAQGKFEKPEAFIPFSLGKRSC 451

  Fly   451 LGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKR 503
            .|::|||..:|.|....:|.||:..|.....|:....|:||:|||:|:.|..|
Zfish   452 PGESLARMELFLFFTSFLQSFSLSAPDETQTSLDFKFGMTLSPKPFKICFTPR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	145/478 (30%)
cyp2v1	NP_001009890.1	p450	46..501	CDD:278495	145/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68091
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920