DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2k16

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001005963.2	Gene:	cyp2k16 / 449790	ZFINID:	ZDB-GENE-041010-37	Length:	502	Species:	Danio rerio

Alignment Length:	519	Identity:	153/519 - (29%)
Similarity:	236/519 - (45%)	Gaps:	56/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSDLV 71
            :|.:|:..|.|.|...::..:|.||||:.:|.|||.|..     .|...|:.....||.| ..:.
Zfish    17 ICFLLLLLVAYLLFLRSQSDENEPPGPKPLPLLGNLLML-----DVNKPHLSLCEMAKQF-GPVF 75

  Fly    72 GLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRHFAM 134
            .:..|.:.|||..|::.||:  |...|.|..|.........|.|  .||...:|:.|.|.|.||:
Zfish    76 KVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFHDFTKG--HGIIFANGESWREMRRFAL 138

  Fly   135 KQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDG 199
            ..:|:.|.|:.::|..|..|...|..:.|:.|.:|.|....:..:..:|:..::.|:|. ...|.
Zfish   139 TNLRDFGMGKKKIEEKIIEETCHLREEFEKFEGKPFETAQLMNYAASSVISSIVYGRRF-EYTDP 202

  Fly   200 TLRRLLDLMNRRSKL-----------FDICGGLLAQFPWLR---HVAPDRTG---YNLIQQLNTE 247
            .||.::|..|...:|           |...|.||..:..|.   |:..:...   ..|.|.||.:
Zfish   203 QLRTMVDRANESVRLSGSASVQLYNMFPFLGPLLKNWRQLMKNLHLDIEEISELVNGLHQTLNHQ 267

  Fly   248 LYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQ 312
            ....|:|:... |:|.|:|                    :|.:.|.|:|..|:.|:.:.|:||:.
Zfish   268 DLRGFVDSFLV-RKQYAED--------------------SGEKDSHFHEQNLIYTVGNLFVAGTD 311

  Fly   313 TTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHIT 377
            |||.|:..:|:::|..|.:|:::..::...:....    |....|:...|.||.|.|.||..:|.
Zfish   312 TTSTTLRWSLLLMAKYPHIQDRVQEEIDQVIGGRQ----PVSEDRKNLPYTDAVIHETQRLANIV 372

  Fly   378 PITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMP 442
            |::.|..........||.|.|...|...|.||..|::.|:.|..|.|..|:|..|:..|.:.|||
Zfish   373 PMSIPHMTSSDITFNGYFIKKGTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMP 437

  Fly   443 FGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGES-PSMVLLP--GITLTPKPYKVQFVKR 503
            |..|||.|||::|||..:|.|...::|:|....|.|.| ..:.|.|  |.||.|..:|:..|||
Zfish   438 FSAGRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVGFTLNPIAHKLCAVKR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	144/491 (29%)
cyp2k16	NP_001005963.2	p450	58..497	CDD:278495	134/467 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010