DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c68

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001034644.2	Gene:	Cyp2c68 / 433247	MGIID:	3612287	Length:	491	Species:	Mus musculus

Alignment Length:	524	Identity:	129/524 - (24%)
Similarity:	228/524 - (43%)	Gaps:	59/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |...:.|...|...::.||........|.||||..:|.:||             .|::.   .||
Mouse     1 MDPFVVLVLCLSFLLLLSLWRQRSARGNLPPGPTPLPIIGN-------------YHLID---MKD 49

  Fly    66 FRSDLVG----------LKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRT---MGTR 115
            ....|..          |..|.:.:|:..|:|.:||  :...|.|.||.     |:..   :...
Mouse    50 IGQCLTNFSKIYGPVFTLYFGSQPIVILHGYEAMKEAFIDYGEEFSGRG-----RIPVFDKVSKG 109

  Fly   116 KGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSV 180
            |||..:.|.:|...|.|.:..:||:|.|:..:|..::.||:.|:.:|::|...|.:|...:..:.
Mouse   110 KGIGFSHGNVWKATRVFTVNTLRNLGMGKRTIETKVQEEAQWLMKELKKTNGSPCDPQFIIGCAP 174

  Fly   181 LNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQF----PWLRHVAPDRTGYNLI 241
            .||:..::...|...::    :..|.|:.:.::..:|......|.    |.|....|.  .:|..
Mouse   175 CNVICSIVFQNRFDYKD----KDFLSLIGKVNECTEILSSPECQIFNAVPILIDYCPG--SHNKF 233

  Fly   242 QQLNTELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILD 305
            .:.:|.:..:.::.|:||...| ..:|    .|.:..:|.:.:.:: |.|...:....|...:.|
Mouse   234 LKNHTWIKSYLLEKIKEHEESLDVTNP----RDFVDYFLIQRRQKN-GIEHMDYTIEHLATLVTD 293

  Fly   306 FFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEV 370
            ....|::|.|:|:..||::|.....:..|:..::...:....:   |.:..|....|.:|.:.||
Mouse   294 LVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRS---PCMQDRNHMPYTNAMVHEV 355

  Fly   371 QRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCF 435
            ||:..:.|..........||...|.|||...::.||.||..|...:.:|..|.|..|:|..|...
Mouse   356 QRYIDLGPNGVVHEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTEFPNPEVFDPGHFLDDNGNFK 420

  Fly   436 KDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLP---GITLTPKPYK 497
            |.:|||||..|:|.|:|::|||..:|.||..|:|:|. :.|..:...:.:.|   |.:..|..::
Mouse   421 KSDYFMPFSAGKRICVGESLARMELFLFLTTILQNFK-LKPLVDPKDIDMTPKHSGFSKIPPNFQ 484

  Fly   498 VQFV 501
            :.|:
Mouse   485 MCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	122/492 (25%)
Cyp2c68	NP_001034644.2	p450	30..487	CDD:278495	122/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920