DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2aa4

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	XP_017209028.1	Gene:	cyp2aa4 / 415182	ZFINID:	ZDB-GENE-040625-72	Length:	505	Species:	Danio rerio

Alignment Length:	510	Identity:	157/510 - (30%)
Similarity:	247/510 - (48%)	Gaps:	63/510 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHIL-----FERWAKDFRSD 69
            :|:.|.|:.:.|...|   |||||..:|::||.            .|:|     |.|....: .:
Zfish    23 LLVLFEIFRIHSYKSR---FPPGPTPLPFVGNL------------PHLLRDPMGFNRLMAQY-GE 71

  Fly    70 LVGLKLGREYVVVALGHEMVKEVQLQEVFEGRP-----DNFFLRLRTMGTRKG---ITCTDGQLW 126
            :..:.||::..:|....::.||..:||.|.|||     |         .|..|   |..|....|
Zfish    72 MSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVID---------WTSNGCGIIMATFNNSW 127

  Fly   127 YEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGK 191
            .:.|.||:..:||.|.|:..:|..:..|::.|..:|.:.|.:|:.|...|..:|.|:...::.|:
Zfish   128 KQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDEGEPVNPHHALQNAVSNIFCSIMFGE 192

  Fly   192 RIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQF----PWLRHV-APDRTGYNLIQQLNTELYGF 251
            |. ..::..|..||.::|....|   .|..:.|.    |:::|. .|    :..|::.:.|||.|
Zfish   193 RF-DYDNKRLGYLLKILNENMML---TGSAIGQIFNLAPFIKHFPGP----HQKIKKNSNELYSF 249

  Fly   252 FMDTIEEHRRQLAKDP-SPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTS 315
            ..|.:||||:.|  || ||  .|.|.|||.|: ::....:.|||.|..|:.:.:|.|.||:.:|:
Zfish   250 IEDEVEEHRKTL--DPVSP--RDFIDAYLLEI-EKQKSNKDSTFQEENLIGSAIDLFFAGTDSTA 309

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            .:|...|:.|...|||||:...::   |.....|..|.:...:...|..|.:.|:|||....|..
Zfish   310 TSIRWGLLFLIQNPDVQERCHEEI---VQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFG 371

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            .....:|.|||.|:|||:...|:.:|.::...|||||.|..|.||.|:|..|...|.|.::||.:
Zfish   372 VFHETIWPTKLHGFDIPQGTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSL 436

  Fly   446 GRRRCLGDALARACIFSFLVRIVQ--HFSVVLPAGESPSMVLLPGITLTPKPYKV 498
            |.|.|||:.||:..:|.|:..::|  .|| .||..:...|..:.||...|:|:.:
Zfish   437 GPRSCLGETLAKTELFLFITSLLQRIRFS-WLPDAKPLDMDGIMGIVRYPQPFSI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	151/490 (31%)
cyp2aa4	XP_017209028.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920