DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2x7

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001243106.1	Gene:	cyp2x7 / 402847	ZFINID:	ZDB-GENE-110114-2	Length:	491	Species:	Danio rerio

Alignment Length:	526	Identity:	166/526 - (31%)
Similarity:	255/526 - (48%)	Gaps:	66/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFR-----KEASAVGGQHILFE 60
            :|.||.:|..|:.|:|     ..:|||||||||..||..||.||..     ||          ||
Zfish     4 VSVLILICIFLVFFLI-----RIKRPKNFPPGPPPVPIFGNLLQINMVDPLKE----------FE 53

  Fly    61 RWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTD- 122
            |.|:.: .::..|..|.:..|.....|::||  |...:.|.|||.:  |.:..:...||:...|
Zfish    54 RLAEKY-GNIFSLYTGSKPAVFLNNFEVIKEALVTKAQDFSGRPQD--LMISHLTGNKGVVLADY 115

  Fly   123 GQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCL 187
            |.||.:||.||:..:||.|.|:..||..|..|...::..|::...:.::|.........||:..:
Zfish   116 GPLWKDHRRFALMTLRNFGLGKQSMEERILGEISHIVDFLDKNTGKTVDPQIMFHNIASNVINLV 180

  Fly   188 IAGKRIARQED---GTLRRL---LDLMNRR-SKLFDICGGLLAQFPWLRHV-APDRTGYN---LI 241
            :.|.|.....:   |.::|:   |.::|.. :.::|       .||.||.: .|.:..::   :|
Zfish   181 LFGCRFDYNNEFLRGYIQRIAENLRILNGPWNMIYD-------TFPLLRILPLPFKKAFDNVKII 238

  Fly   242 QQLNTELYGFFMDTIEEHRRQLAKDPSPAE-SDLIYAYLQEM-KDRSAGGESSTFNETQLVMTIL 304
            :.:|.:|       |:||:....    |.: .|.|..||.|: |.::.   .|||:|.||:|.|:
Zfish   239 KSMNRKL-------IDEHKSTRV----PGQPRDFIDCYLDELDKVKNC---VSTFSEDQLIMNIM 289

  Fly   305 DFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIME 369
            |...||:.|||||:..|.:.|...|:||.|...::...:.......:   ..|....|..|.|.|
Zfish   290 DMSFAGTDTTSNTLLAAFLYLMNHPEVQVKCQQEIDDVLEGKDQVTY---EDRHNMPYTLAVIHE 351

  Fly   370 VQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKC 434
            |||..:|.|::........|:|.||.|||...|:.:|..|..::..||.|.||.|..|::..|:.
Zfish   352 VQRVANIVPLSVLHCTTRDTELMGYSIPKGTVIIPNLTVVLKEEGQWKFPHEFNPANFLNEQGQF 416

  Fly   435 FKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLP--AGESPSMVLLPGITLTPKPYK 497
            .|.|.|:||..|.|.|||:.|||..:|...|.:::.|..|.|  ||: |....:.|:|:|||||:
Zfish   417 EKPEAFIPFSTGPRVCLGEGLARMELFLIFVTLLRRFQFVWPEDAGK-PDYTPVFGLTMTPKPYR 480

  Fly   498 VQFVKR 503
            :...:|
Zfish   481 MHIRRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	153/492 (31%)
cyp2x7	NP_001243106.1	p450	36..479	CDD:278495	145/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920