DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2k6

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_956803.2	Gene:	cyp2k6 / 393481	ZFINID:	ZDB-GENE-040426-1571	Length:	505	Species:	Danio rerio

Alignment Length:	528	Identity:	158/528 - (29%)
Similarity:	246/528 - (46%)	Gaps:	70/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCAILIGFVIY--SLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSD 69
            |.|:|:..|||  |..||::..:.:||||:.:|.|||.             |||      |.:..
Zfish    18 LGALLLFLVIYLFSSSSSSQDKEKYPPGPKPLPLLGNL-------------HIL------DLKKT 63

  Fly    70 LVG-LKLGREY------------VVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGIT 119
            .:. |:|.::|            ||:..|:::|||  |.|.|.|..|..:........|  .||.
Zfish    64 YLSLLELSKKYGPIYTVYLGPKKVVILSGYKIVKEALVNLSEEFGDRDISPIFHDFNRG--YGIA 126

  Fly   120 CTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVL 184
            .::|:.|.|.|.||:..:|:.|.||.:.|..|..|.:.:..:.|:....|.|....||.::.|::
Zfish   127 FSNGENWREMRRFALSTLRDFGMGRKRSEELIIEEIKYVKEEFEKFGGNPFETKLPLALAISNII 191

  Fly   185 WCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQ----FPWLRHVAPDRTGYNLIQQL- 244
            ..::...|. ...:..|.|::.......||   .|....|    |||||.:..:|.  .:::.|
Zfish   192 ASIVFSVRF-EYSNTKLHRMVGRAYENMKL---TGSPSVQIYNMFPWLRPIVANRN--QIVKNLR 250

  Fly   245 -----NTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTIL 304
                 |.||....|.|:         ||......:....:::.||..:|...|.:|...|..|:.
Zfish   251 DTFKQNEELINGVMKTL---------DPFNPRGIVDSFLIRQQKDEESGKTDSLYNSNNLYCTVN 306

  Fly   305 DFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIME 369
            :.|.||:.||..|:...|:::|..|::|.|:..::...:....    |.:..|:...|.||.|.|
Zfish   307 NLFGAGTDTTVTTLRWGLLLMAKYPEIQAKVQDEIERVIGGRQ----PVVEDRKNLPYTDAVIHE 367

  Fly   370 VQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKC 434
            :|||..|:||..||:......|.||.|.|...:...|.||..|:..|:.|..|.|:.|::..|:.
Zfish   368 IQRFADISPIGAPRQTTCDVHLNGYFIKKGTPVFPLLVSVLRDENEWETPDSFNPKHFLNKQGQF 432

  Fly   435 FKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGES-PSMVLLP--GITLTPKPY 496
            .|.:.|||||.|||.|:|::|||..:|.|...::|:|....|.|.| ..:.|.|  |.||.|||:
Zfish   433 VKKDAFMPFGAGRRVCIGESLARMELFLFFTSLLQYFRFTPPPGVSEDDLDLTPVVGFTLNPKPH 497

  Fly   497 KVQFVKRT 504
            ::..|||:
Zfish   498 QLCAVKRS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	146/497 (29%)
cyp2k6	NP_956803.2	p450	64..500	CDD:306555	134/456 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010