DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp305a1 and cyp2p6

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_956433.1	Gene:	cyp2p6 / 393108	ZFINID:	ZDB-GENE-040426-790	Length:	496	Species:	Danio rerio

Alignment Length:	515	Identity:	154/515 - (29%)
Similarity:	256/515 - (49%)	Gaps:	45/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNT--LQFRKEASAVGGQHILFERWAK 64
            :.|.|.|.    |::.|.....:.||||||||..:|.:||.  :.|.|       .|:..|:.::
Zfish    14 AVLFFACV----FLLLSNYIRNKTPKNFPPGPWPLPIIGNLYHIDFNK-------IHLEVEKLSE 67

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLR-----LRTMGTRKGITCTDGQ 124
            .:.| :|.:.|..:..|:..|::.||||.:|:     .||...|     :..:....|:....|.
Zfish    68 KYGS-VVSVHLFGQRTVILNGYKQVKEVYIQQ-----GDNVADRPELPMIHDIAGDNGLVAPSGY 126

  Fly   125 LWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIA 189
            .|.:.|.||:..:||.|.|:..:|..|.||...|...:.....:|.:|...|..::.||:..|:.
Zfish   127 KWKQQRRFALSTLRNFGLGKKSLEPSINLECHYLNEAISNENGRPFDPHLLLNNAISNVICVLVF 191

  Fly   190 GKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQ----FPWLRHVAPDRTGYNLIQQLNTELYG 250
            |.|.    |.:......|:|..::...:.|.:.||    :|.:..:.|.....|:  .|..::..
Zfish   192 GNRF----DYSDHHFQTLLNDINEAMYLDGTIWAQLYNSYPRIMRLLPGPHKKNI--TLWNKVID 250

  Fly   251 FFMDTIEEHRRQLAKDPSPAES--DLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQT 313
            |..:.::|||  :..|||....  |...|.::::||.:|.|    |:...|.:..||.|:||::|
Zfish   251 FARERVKEHR--VDYDPSNPRDYVDCFLAEMEKLKDDTAAG----FDVENLCICTLDLFVAGTET 309

  Fly   314 TSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITP 378
            ||.|::.:|:.:...|::|.|:..::...:.::   ..|.:|.|:...|.:|.|.|:|||.:|..
Zfish   310 TSTTLSWSLLYMIKYPEIQAKVQEEIDRVIGSS---RHPSVSDRDNMPYTNAVIHEIQRFGNIAA 371

  Fly   379 ITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPF 443
            :..||.|:...::|.|.|||...::.:|.||..|:..|:.|..|.|..|:|:.||..:.:.|:||
Zfish   372 LNLPRAAVKDIQVGKYLIPKGTIVIGNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPF 436

  Fly   444 GMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKR 503
            .:|:|.|||:.|||..:|.|...::|||:...|||..||.....|.|..|||:|:..|.|
Zfish   437 SLGKRVCLGEQLARMELFLFFTSLLQHFTFSSPAGVEPSFNYKLGTTRAPKPFKLCAVSR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	143/482 (30%)
cyp2p6	NP_956433.1	p450	38..492	CDD:278495	143/481 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68091
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920