DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2t4

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001093654.1	Gene:	Cyp2t4 / 384724	MGIID:	2686296	Length:	503	Species:	Mus musculus

Alignment Length:	530	Identity:	165/530 - (31%)
Similarity:	244/530 - (46%)	Gaps:	69/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALIFLCAILI-----GFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRK--------EASAVGG 54
            ||:.|..||:     |.|:.   ..|:..|:.||||..:|.|||.||.:.        |.|:..|
Mouse    14 ALLLLLLILMLLLWWGGVVR---RQAQMQKDLPPGPAPLPLLGNLLQLQSGDLDRVLMELSSHWG 75

  Fly    55 QHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRP-----DNFFLRLRTM 112
            .  :|..|            ||....||..|:|.:::  |...:.|.||.     |.|     |.
Mouse    76 P--VFTVW------------LGPLPAVVLCGYEALRDALVLQADAFSGRGAMAVFDRF-----TC 121

  Fly   113 GTRKGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLA 177
            |  .||..::|..|:..|:||:..:|.:|.|||.:|..|..||..:|.:.:.|...|.:|...|.
Mouse   122 G--NGIVFSNGPRWHSLRNFALGVLRELGVGRSTIEDRILEEAACVLDEFQATMGAPFDPQQLLD 184

  Fly   178 QSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQ----FPWLRHVAPDRTGY 238
            .:|.||:..::.|||. ...|...||||:|.   |..|.|.....|:    ||......|.  .:
Mouse   185 SAVSNVICTVVFGKRY-DYGDPEFRRLLNLF---SDNFCIMSSRWAEIYNMFPSFMDWIPG--PH 243

  Fly   239 NLIQQLNTELYGFFMDTIEEH--RRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVM 301
            |.|.:...||..|..:.|:.|  .||..:     ..|.|..:|.:| |:......|.|.:..|||
Mouse   244 NRIFKNFQELRLFISEQIQWHWQSRQTGE-----PRDFIDCFLDQM-DKEQQDLESHFQDETLVM 302

  Fly   302 TILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAF 366
            |..|.|..|::|||.|:...|:::...|:|..|:..::.|:|.....   |.:..|....|.:|.
Mouse   303 TTHDLFFGGTETTSTTLRYGLLIMLKYPEVAAKVQEELDATVGRTWA---PRIEDRARLPYTNAV 364

  Fly   367 IMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSA 431
            :.|:|||..:.|:..||.......|..:.:.|...::..|.|.|.|...:|||..|.|..|:|..
Mouse   365 LHEIQRFISVLPLGLPRALTRDVNLKNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDH 429

  Fly   432 GKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLP---GITLTP 493
            |:...::.||||.:|:|.|||..|||:.||.||..|:|.|| :||.|...::.|.|   |:...|
Mouse   430 GEFQNNDAFMPFALGKRMCLGAGLARSEIFLFLTAILQKFS-LLPVGSPANINLNPQCTGLGNVP 493

  Fly   494 KPYKVQFVKR 503
            ..::::.|.|
Mouse   494 PAFQLRLVAR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	154/493 (31%)
Cyp2t4	NP_001093654.1	p450	63..498	CDD:278495	144/471 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010