DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2u1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001380742.1	Gene:	Cyp2u1 / 310848	RGDID:	1309433	Length:	530	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	164/540 - (30%)
Similarity:	260/540 - (48%)	Gaps:	78/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLC--AILIGFVIYSLISSARRPKNFPPGPRFVP------------------WLGNTLQFRKEA 49
            :.||  |:|:.:|..    ..:|....||||:..|                  |||:..|
  Rat    28 LLLCGLAVLLDWVWL----QRQRAGGIPPGPKPRPLVGNFGYLLLPRFLRLHFWLGSGSQ----- 83

  Fly    50 SAVGGQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTM 112
            :...|:|:...|.|:.: .::....:|...|||....:.|:|  ||..|||..||....:.:.|
  Rat    84 TDTVGRHVYLARLARVY-GNIFSFFIGHRLVVVLSDFQSVREALVQQAEVFSDRPRMPLISILT- 146

  Fly   113 GTRKGITCTD-GQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWL 176
             ..|||.... |.:|.:.|.|:...:|:.|.|:..:|..|..|...:..::::..|.|..|...:
  Rat   147 -KEKGIVFAHYGPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKAEMQKHGEAPFSPFPVI 210

  Fly   177 AQSVLNVLWCLIAGKRIARQEDGT---LRRLLDLMNR------RSKLF--DICGGLLAQFPWLRH 230
            :.:|.|::..|..|:|.    |.|   .:::||.|:|      .|:||  ::|       ||..:
  Rat   211 SNAVSNIICSLCFGQRF----DYTNKEFKKVLDFMSRGLEICLHSQLFLINLC-------PWFYY 264

  Fly   231 V--APDRTGYNLIQQLNTELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYL---QEMKDRSAGG 289
            :  .|    :..::|:..::..|..:.|:||:..| |.:|    .|.|..||   ||.||:..|
  Rat   265 LPFGP----FKELRQIERDITCFLKNIIKEHQESLDANNP----QDFIDMYLLHTQEEKDKCKG- 320

  Fly   290 ESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHL 354
              :.|:|..|...|.|.||||:.||:|::...|:.:::.|.||:|:..::...:   ..|..|.|
  Rat   321 --TNFDEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPGVQKKVHEEIERVI---GRDRAPSL 380

  Fly   355 SRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDP 419
            :.:....|.:|.||||||...:.|:..|......|.|.||.|||...:|.:|.|:|.|...|:.|
  Rat   381 TDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKTVLQGYSIPKGTVVLPNLWSIHRDPVIWEKP 445

  Fly   420 LEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAG-ESPSM 483
            .:|.|.||:|..|:..|.|.|:|||:|:|.|:|:.||:..:|...|.::|.|:..||.| |.|.|
  Rat   446 DDFCPHRFLDDQGQLLKRETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFALPEGSEKPIM 510

  Fly   484 VLLPGITLTPKPYKVQFVKR 503
            ....|:||.|.|:.|...||
  Rat   511 TGRFGLTLAPHPFNVTVSKR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	156/508 (31%)
Cyp2u1	NP_001380742.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920