DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001100965.1	Gene:	Cyp2s1 / 308445	RGDID:	1306078	Length:	499	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	150/517 - (29%)
Similarity:	247/517 - (47%)	Gaps:	60/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AILIGFVIYSL-ISSARRPK--NFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSDL 70
            |:|:..::..| ::..|.|.  ..||||..:|.|||.||.|..|...|     |.|.:|.: ..:
  Rat     8 ALLLALLLLLLALTLPRTPARGQLPPGPTPLPLLGNLLQLRPGALYSG-----FLRLSKKY-GPV 66

  Fly    71 VGLKLGR-EYVVVALGHEMVKEV---QLQEVFEGRPDNFFLRLRTMGT------RKGITCTDGQL 125
            ..:.||. ..|||.:||:.::|.   |.:| |.||        .|:.|      ..|:...:|:.
  Rat    67 FTVHLGPWRRVVVLVGHDAIREALGGQAEE-FSGR--------GTLATLDKTFDGHGVFFANGER 122

  Fly   126 WYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAG 190
            |.:.|.|.:..:|::|.|:.:.|..|:.|.:.|:...:|||.:|..|...|||:..||:..||.|
  Rat   123 WKQLRKFTLLALRDLGMGKREGEELIQEEVQNLVKAFQRTEGRPFNPSMLLAQATSNVVCSLIFG 187

  Fly   191 KRIARQE----------DGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLN 245
            .|:..::          .||   ||.:.:...:.:::       |.||....|.  .:..:|...
  Rat   188 IRLPYEDKEFQAVIQAASGT---LLGISSPWGQAYEM-------FSWLLQPLPG--PHTQLQHHL 240

  Fly   246 TELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEM-KDRSAGGESSTFNETQLVMTILDFFIA 309
            ..|..|.:..::.|:.: :....||. |::.|:||:| :::...|  :.|.|..|:||:.....|
  Rat   241 GTLAAFTIQQVQRHQGR-SHTSGPAR-DVVDAFLQKMAQEKEDPG--TEFTEKNLLMTVTYLLFA 301

  Fly   310 GSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFF 374
            |:.|...||..||::|...|.||:::..::...:..:.|   |.||.|....|.||.:.|.||..
  Rat   302 GTMTIGATIRYALLLLLKYPQVQKRVREELIQELGPSRT---PSLSDRVRLPYTDAVLHEAQRLL 363

  Fly   375 HITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEY 439
            .:.|:..|......|...||.:||...:...:.||..|...:::|.||.|.||:|..|:..|.|.
  Rat   364 ALVPMGMPHTVTKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRIRKHEA 428

  Fly   440 FMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLTPKPYKVQ 499
            |:|:.:|:|.|||:.||||.::.|...|:|.||:  ..|.|:......:.|:...|..:::|
  Rat   429 FLPYSLGKRVCLGEGLARAELWLFFTSILQAFSLDTPCPPGDLSLKPAVRGLFNIPPDFQLQ 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	145/493 (29%)
Cyp2s1	NP_001100965.1	p450	48..491	CDD:365848	135/477 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920