Protein Alignment Cyp305a1 and CYP2S1

DIOPT Version :9

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_085125.1
• Gene: CYP2S1 / 29785
• HGNCID: 15654
• Length: 504
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 154/523 - (29%)
• Similarity: 247/523 - (47%)
• Gaps: 84/523 - (16%)

  Fly     3 ALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFR 67
            ||:...|:|:  ::...:|..|...:.||||..:|.|||.||.|..|...|
Human     8 ALLLALALLL--LLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSG-------------- 56

  Fly    68 SDLVGLKLGREY-------------VVVALGHEMVKEV---QLQEVFEGRPDNFFLRLRTMGT-- 114
                .::|.::|             |||.:|.|.|:|.   |.:| |.||.....|.    ||
Human    57 ----LMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEE-FSGRGTVAMLE----GTFD 112

  Fly   115 RKGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQS 179
            ..|:..::|:.|.:.|.|.|..:|::|.|:.:.|..|:.||..|:...:.||.:|.:|...|||:
Human   113 GHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQA 177

  Fly   180 VLNVLWCLIAGKR----------IARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPD 234
            ..||:..|:.|.|          :.|...||   ||.:.::..:.:::....|...|     .|.
Human   178 TSNVVCSLLFGLRFSYEDKEFQAVVRAAGGT---LLGVSSQGGQTYEMFSWFLRPLP-----GPH 234

  Fly   235 RTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEM--KDRSAGGESSTFNET 297
            :   .|:..::| |..|.:..:::|:..|  |.|....||:.|:|.:|  ::::.|.|   |...
Human   235 K---QLLHHVST-LAAFTVRQVQQHQGNL--DASGPARDLVDAFLLKMAQEEQNPGTE---FTNK 290

  Fly   298 QLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDY 362
            .::||::....||:.|.|.|:...|::|...|.||:.:..::...:.|...   |.|..|....|
Human   291 NMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQA---PSLGDRTRLPY 352

  Fly   363 MDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERF 427
            .||.:.|.||...:.|:..||..:..|:..||.:|:...:...|.|:..|...:|.|.||.|:||
Human   353 TDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRF 417

  Fly   428 IDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLT 492
            :|:.|:..|.|.|:||.:|:|.|||:.||:|.:|.|...|:|.||:     |||    .|..||:
Human   418 LDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSL-----ESP----CPPDTLS 473

  Fly   493 PKP 495
            .||
Human   474 LKP 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	148/496 (30%)
CYP2S1	NP_085125.1	p450	49..488	CDD:365848	138/480 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920