DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c6v1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001013926.2	Gene:	Cyp2c6v1 / 293989	RGDID:	619934	Length:	490	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	145/529 - (27%)
Similarity:	222/529 - (41%)	Gaps:	69/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |..::.|...|...::.|:...:......||||..:|.:||                :|:...|:
  Rat     1 MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGN----------------IFQLNVKN 49

  Fly    66 FRSDLVG----------LKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRKGITC 120
            ....|..          |..|.:..|:..|:|.|||..:....|......|.....:....||..
  Rat    50 ITQSLTSFSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDLGIVF 114

  Fly   121 TDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLW 185
            :.|..|.|.|.|.:..:||:|.|:..:|..::.||..|:.:|.:|...|.:|...|..:..||:.
  Rat   115 SHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVIC 179

  Fly   186 CLIAGKRIARQEDGTLRRLLDLMNRRSK---------------LFDICGGLLAQFPWLRHVAPDR 235
            .:|...|...::...| .|::.:|...|               |.|.|.|        .|....:
  Rat   180 SIIFQNRFDYKDQDFL-NLMEKLNENMKILSSPWTQFCSFFPVLIDYCPG--------SHTTLAK 235

  Fly   236 TGYNLIQQLNTELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQL 299
            ..|:        :..:.:..|:||:..| ..:|    .|.|..||.:.|..:....|. |....|
  Rat   236 NVYH--------IRNYLLKKIKEHQESLDVTNP----RDFIDYYLIKWKQENHNPHSE-FTLENL 287

  Fly   300 VMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMD 364
            .:|:.|.|.||::|||.|:..||::|...|:|..|:..::...|....:   |.:..|....|.|
  Rat   288 SITVTDLFGAGTETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKHRS---PCMQDRSRMPYTD 349

  Fly   365 AFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFID 429
            |.|.|||||..:.|...|.......|...|.|||..||:.||.||..|.:.:.||..|.|..|:|
  Rat   350 AMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLD 414

  Fly   430 SAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLT 492
            ..||..|.:|||||..|:|.|.|:.|||..:|.||..|:|:|.:  ||...:..:..:..|....
  Rat   415 GNGKFKKSDYFMPFSAGKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKDIDTTPVFNGFASL 479

  Fly   493 PKPYKVQFV 501
            |..|::.|:
  Rat   480 PPFYELCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	140/497 (28%)
Cyp2c6v1	NP_001013926.2	CYP2C-like	61..485	CDD:410758	130/448 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010