DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c7

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_058854.1	Gene:	Cyp2c7 / 29298	RGDID:	620379	Length:	490	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	150/517 - (29%)
Similarity:	237/517 - (45%)	Gaps:	45/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFR-KEASAVGGQHILFERWAK 64
            |..:.||...|...::.||...:.|.:..||||..:|.:||.||.. |..|.      ...:::|
  Rat     1 MDLVTFLVLTLSSLILLSLWRQSSRRRKLPPGPTPLPIIGNFLQIDVKNISQ------SLTKFSK 59

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGITCTDGQLWY 127
            .: ..:..|.||.:..|:..|:|.:||..:.  |.|.||.........|.|.  ||..::|..|.
  Rat    60 TY-GPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMNENVTKGF--GIVFSNGNRWK 121

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |.|.|.:...||:|.|:..:|..::.||:.|:.:|.:|:..|.:|...|..:..||: |.|..:.
  Rat   122 EMRRFTIMNFRNLGIGKRNIEDRVQEEAQCLVEELRKTKGSPCDPSLILNCAPCNVI-CSITFQN 185

  Fly   193 IARQEDGTLRRLLDLMNRRSKL-----FDICG---GLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            ....:|..:...::.:|...|:     ..:|.   .|:..||...|.......|         :.
  Rat   186 HFDYKDKEMLTFMEKVNENLKIMSSPWMQVCNSFPSLIDYFPGTHHKIAKNINY---------MK 241

  Fly   250 GFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGG-ESSTFNETQLVMTILDFFIAGSQ 312
            .:.:..||||:..| ..:|    .|.:..||  :|.:.|.. |.|.::...|..:|:|...||::
  Rat   242 SYLLKKIEEHQESLDVTNP----RDFVDYYL--IKQKQANNIEQSEYSHENLTCSIMDLIGAGTE 300

  Fly   313 TTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHIT 377
            |.|.|:..||::|...|.|..|:..::...:....:   |.:..|:...|.||.|.|||||.:..
  Rat   301 TMSTTLRYALLLLMKYPHVTAKVQEEIDRVIGRHRS---PCMQDRKHMPYTDAMIHEVQRFINFV 362

  Fly   378 PITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMP 442
            |...|.......|...|.|||...:|.||.||..|.:.:.:|..|.|..|:|..|...|.:||:|
  Rat   363 PTNLPHAVTCDIKFRNYLIPKGTKVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFLP 427

  Fly   443 FGMGRRRCLGDALARACIFSFLVRIVQHF---SVVLPAGESPSMVLLPGITLTPKPYKVQFV 501
            |..|:|.|:|:.|||..:|.||..|:|:|   |:|.|. :..:|.:|.|....|..|::.|:
  Rat   428 FSAGKRACVGEGLARMQLFLFLTTILQNFNLKSLVHPK-DIDTMPVLNGFASLPPTYQLCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	142/485 (29%)
Cyp2c7	NP_058854.1	p450	30..487	CDD:278495	142/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920