Protein Alignment Cyp305a1 and Cyp2b12

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_058852.2
• Gene: Cyp2b12 / 29295
• RGDID: 620088
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 518
• Identity: 159/518 - (30%)
• Similarity: 257/518 - (49%)
• Gaps: 48/518 - (9%)

  Fly     4 LIFLCAILIGFVIYSLISSARRPK---NFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            ::.|..:.:||::: |:|.: :||   :.|||||.:|:|||.||..:. ..:.....|.|::
  Rat     5 VLLLLTLTVGFLLF-LVSQS-QPKTHGHLPPGPRPLPFLGNLLQMNRR-GFLNSFMQLQEKY--- 63

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYE 128
              .|:..:.||...||:..|.:.::|  |...|.|.||.....|.....|  .|:....|:.|..
  Rat    64 --GDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQG--YGVIFATGERWKT 124

  Fly   129 HRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSV-LNVLWCLIAGKR 192
            .|.|::..|:..|.|:..::..|:.||:.|:.:|::.:..|:.| |:|.||: .|.:..::.|:|
  Rat   125 LRRFSLVTMKEFGMGKRSVDERIKEEAQCLVEELKKYKGAPLNP-TFLFQSIAANTICSIVFGER 188

  Fly   193 IARQEDGTLRRLLDLMNR--------RSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            . ..:|.....||||:.:        .|::|::..|.|..||.    |..:...||.:.||
  Rat   189 F-DYKDHQFLHLLDLVYKTSVLMGSLSSQVFELYSGFLKYFPG----AHKQIFKNLQEMLN---- 244

  Fly   250 GFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTT 314
             :....:|:||..|  ||| |..|.|..||..| ::......:.||...||:::|..|.||::||
  Rat   245 -YIGHIVEKHRATL--DPS-APRDFIDTYLLRM-EKEKSNHHTEFNHQNLVISVLSLFFAGTETT 304

  Fly   315 SNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPI 379
            |.|:....:::...|.|.||:..::...:   .:...|....|....|.||.|.|:|||..:|||
  Rat   305 STTLRCTFLIMLKYPHVAEKVQKEIDQVI---GSHRLPTPDDRTKMPYTDAVIHEIQRFADLTPI 366

  Fly   380 TGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFG 444
            ..|.|....|...||.:|||..:...|.|...|..:::.|..|.||.|:|:.|...|.|.|:||.
  Rat   367 GLPHRVTKDTVFRGYLLPKNTEVYPILSSALHDPRYFEQPDTFNPEHFLDANGALKKSEAFLPFS 431

  Fly   445 MGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMV-LLP---GITLTPKPYKVQFVKR 503
            .|:|.|||:.:||..:|.|...|:|:|::..|.  :|..: |.|   |:...|.||::.|:.|
  Rat   432 TGKRICLGEGIARNELFIFFTAILQNFTLASPV--APEDIDLTPINSGVGKIPSPYQINFLSR 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	137/444 (31%)
Cyp2b12	NP_058852.2	CYP2B	63..487	CDD:410765	137/450 (30%)