DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c11

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_062057.2	Gene:	Cyp2c11 / 29277	RGDID:	2469	Length:	500	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	150/503 - (29%)
Similarity:	239/503 - (47%)	Gaps:	42/503 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQ-FRKEASAVGGQHILFERWAK 64
            |..::.|...|...::.||...:......||||..:|.:||||| :.|:.    ||.|  ::::|
  Rat     1 MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDI----GQSI--KKFSK 59

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWY 127
            .: ..:..|.||.:..||..|:|.|||  |.|.|.|.||  ..|.....:....|:..::|..|.
  Rat    60 VY-GPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGR--GSFPVSERVNKGLGVIFSNGMQWK 121

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |.|.|::..:|..|.|:..:|..|:.||:.|:.:|.:::..|.:|...|..:..||:..:|...|
  Rat   122 EIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNR 186

  Fly   193 IARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLR--HVAPDRTGY---NLIQQLNTELY--G 250
            . ..:|.|...|:...|...:||        ..|||:  :..|....|   :..|.|....|  .
  Rat   187 F-DYKDPTFLNLMHRFNENFRLF--------SSPWLQVCNTFPAIIDYFPGSHNQVLKNFFYIKN 242

  Fly   251 FFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTS 315
            :.::.::||:..|.|| :|  .|.|..:|.:|:......:|. |....||.|:.|.|.||::|||
  Rat   243 YVLEKVKEHQESLDKD-NP--RDFIDCFLNKMEQEKHNPQSE-FTLESLVATVTDMFGAGTETTS 303

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            .|:...|::|....||..|:..::...:   ..:..|.:..|....|.||.:.|:||:..:.|..
  Rat   304 TTLRYGLLLLLKHVDVTAKVQEEIERVI---GRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVPTN 365

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            .|.......|...|.|||...:::||.|:..|.:.:.:|.:|.|..|:|..|...|.:|||||..
  Rat   366 LPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSA 430

  Fly   446 GRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTP 493
            |:|.|.|:||||..:|.|...|:|:|::       .|:|.:..|..||
  Rat   431 GKRICAGEALARTELFLFFTTILQNFNL-------KSLVDVKDIDTTP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	145/474 (31%)
Cyp2c11	NP_062057.2	p450	30..487	CDD:278495	145/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920