DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2d5

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_775426.1	Gene:	Cyp2d5 / 286963	RGDID:	628630	Length:	504	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	149/488 - (30%)
Similarity:	240/488 - (49%)	Gaps:	36/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RRPKNFPPGPRFVPW--LGNTLQFRKEASAVGGQHILFERWAKDFR-SDLVGLKLGREYVVVALG 85
            |....:||||  |||  |||.||       |...::.:..:....| .|:..|::|.:.:|:...
  Rat    31 RWTSRYPPGP--VPWPVLGNLLQ-------VDPSNMPYSMYKLQHRYGDVFSLQMGWKPMVIVNR 86

  Fly    86 HEMVKEVQL---QEVFEGRPDNFFLRLRTMGTRKGIT-CTDGQLWYEHRHFAMKQMRNVGYGRSQ 146
            .:.|:||.:   ::..:..|...|..|......:|:. .:.|..|.|.|.|::..:|..|.|:..
  Rat    87 LKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVVFASYGPEWREQRRFSVSTLRTFGMGKKS 151

  Fly   147 MEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRR 211
            :|..:..||..|.........:.|.|...|.:::.||:..||..:|. ..||..|.|:|.|:  .
  Rat   152 LEEWVTKEAGHLCDAFTAQNGRSINPKAMLNKALCNVIASLIFARRF-EYEDPYLIRMLTLV--E 213

  Fly   212 SKLFDICG---GLLAQFPWLRHV--APDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAE 271
            ..|.::.|   .:|..||.|..:  ..|:     :.|.......|..:.:.|:|  ...||:...
  Rat   214 ESLIEVSGFIPEVLNTFPALLRIPGLADK-----VFQGQKTFMAFLDNLLAENR--TTWDPAQPP 271

  Fly   272 SDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLF 336
            .:|..|:|.|: :::.|...|:||:..|.|.::|.|.||..||:.|:..||:::.:.||||.::.
  Rat   272 RNLTDAFLAEV-EKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQ 335

  Fly   337 SQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNAT 401
            .::...:.....   |.::.:....|.:|.|.|||||..|.|:..||......::..:.|||..|
  Rat   336 QEIDEVIGQVRC---PEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTT 397

  Fly   402 ILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVR 466
            ::|:|.||..|:..|:.||.|.||.|:|:.|...|.|.||||..|||.|||:.|||..:|.|...
  Rat   398 LIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTC 462

  Fly   467 IVQHFSVVLPAGE-SPSMVLLPGITLTPKPYKV 498
            ::||||..:|||: .||.:....|::.|.||::
  Rat   463 LLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	148/482 (31%)
Cyp2d5	NP_775426.1	p450	37..496	CDD:278495	148/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010