Protein Alignment Cyp305a1 and Cyp2d5

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_775426.1
• Gene: Cyp2d5 / 286963
• RGDID: 628630
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 488
• Identity: 149/488 - (30%)
• Similarity: 240/488 - (49%)
• Gaps: 36/488 - (7%)

  Fly    24 RRPKNFPPGPRFVPW--LGNTLQFRKEASAVGGQHILFERWAKDFR-SDLVGLKLGREYVVVALG 85
            |....:||||  |||  |||.||       |...::.:..:....| .|:..|::|.:.:|:...
  Rat    31 RWTSRYPPGP--VPWPVLGNLLQ-------VDPSNMPYSMYKLQHRYGDVFSLQMGWKPMVIVNR 86

  Fly    86 HEMVKEVQL---QEVFEGRPDNFFLRLRTMGTRKGIT-CTDGQLWYEHRHFAMKQMRNVGYGRSQ 146
            .:.|:||.:   ::..:..|...|..|......:|:. .:.|..|.|.|.|::..:|..|.|:..
  Rat    87 LKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQGVVFASYGPEWREQRRFSVSTLRTFGMGKKS 151

  Fly   147 MEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRR 211
            :|..:..||..|.........:.|.|...|.:::.||:..||..:|. ..||..|.|:|.|:  .
  Rat   152 LEEWVTKEAGHLCDAFTAQNGRSINPKAMLNKALCNVIASLIFARRF-EYEDPYLIRMLTLV--E 213

  Fly   212 SKLFDICG---GLLAQFPWLRHV--APDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAE 271
            ..|.::.|   .:|..||.|..:  ..|:     :.|.......|..:.:.|:|  ...||:...
  Rat   214 ESLIEVSGFIPEVLNTFPALLRIPGLADK-----VFQGQKTFMAFLDNLLAENR--TTWDPAQPP 271

  Fly   272 SDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLF 336
            .:|..|:|.|: :::.|...|:||:..|.|.::|.|.||..||:.|:..||:::.:.||||.::.
  Rat   272 RNLTDAFLAEV-EKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQ 335

  Fly   337 SQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNAT 401
            .::...:.....   |.::.:....|.:|.|.|||||..|.|:..||......::..:.|||..|
  Rat   336 QEIDEVIGQVRC---PEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTT 397

  Fly   402 ILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVR 466
            ::|:|.||..|:..|:.||.|.||.|:|:.|...|.|.||||..|||.|||:.|||..:|.|...
  Rat   398 LIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTC 462

  Fly   467 IVQHFSVVLPAGE-SPSMVLLPGITLTPKPYKV 498
            ::||||..:|||: .||.:....|::.|.||::
  Rat   463 LLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	134/439 (31%)
Cyp2d5	NP_775426.1	CYP2D	68..495	CDD:410756	134/440 (30%)