DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2ad2

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_694486.1	Gene:	cyp2ad2 / 259306	ZFINID:	ZDB-GENE-020812-2	Length:	492	Species:	Danio rerio

Alignment Length:	508	Identity:	145/508 - (28%)
Similarity:	247/508 - (48%)	Gaps:	56/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIGFVIYSLISSA---RRPKNFPPGPRFVPWLGNT---LQFRKEASAVGGQHILFERWAKDFRSD 69
            :|.||::.:|:..   |.|.|:||||..:|:||..   :.|:.           ..:.||.: ..
Zfish    16 IIFFVVFLIIAEMIKNRTPSNYPPGPWPLPFLGTVFTKMDFKN-----------INKLAKVY-GK 68

  Fly    70 LVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRK-----GITCTDGQLWYEH 129
            :..|::|.|.:::..|::||||..:.:     .|:|.||.......|     |:|.::|.:|..|
Zfish    69 VFSLRVGSEKMIIVSGYKMVKEALVTQ-----NDSFVLRPPVPLFHKVYKGIGLTMSNGYIWRSH 128

  Fly   130 RHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIA 194
            |.||...:|..|.|:..:|..|:.|...|.... :.|::|..|:..|..:|.|.:.||..|:|.
Zfish   129 RRFAASHLRTFGEGKKNLELGIQQECVYLCDAF-KAEKEPFNPIFILHGAVSNTVACLTFGQRF- 191

  Fly   195 RQEDGTLRRLLDLMNR--------RSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGF 251
            ...|...:.:|.|.|:        |.:|::....||...|     .|.:..::..:::...|
Zfish   192 DYNDEWYQEILRLDNQCVQLAGSPRVQLYNAFPKLLDYLP-----GPHQKVFSNYKKITQSL--- 248

  Fly   252 FMDTIEEHRRQLAKDPSPAE-SDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTS 315
             .|.|.:||    :|..||. .|.|..||.||:.:.:..::. ||...|:::.||...||::|.:
Zfish   249 -KDEIIKHR----EDWDPANPRDFIDNYLTEMEKKKSDPQAG-FNIESLIISCLDIVEAGTETGA 307

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            .|:...|:.:...|::|:|:.:::...:..:..   |.|..|....|.:|.:.|:|||..:.|:.
Zfish   308 TTLRWGLLFMIKFPEIQKKVQAEIDRVIGQSRQ---PCLDDRVNMPYTEAVLHEIQRFGDVVPLG 369

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            .|::|...||:|.|.|||..:|..:|.||..|...|:.|..|.|..|:|..|:..|.:.|:||..
Zfish   370 FPKQAAVDTKIGNYFIPKGTSITTNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRKRDAFLPFSA 434

  Fly   446 GRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKV 498
            |:|.|:|:.|||..:|.|...::|.|::....||.||:......|..|.|:::
Zfish   435 GKRACVGELLARNVLFLFFTSLLQQFTLSKCPGEEPSLEGEIWFTYAPAPFRI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	138/486 (28%)
cyp2ad2	NP_694486.1	p450	38..470	CDD:278495	133/467 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68091
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920