DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2g1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_036919.1	Gene:	Cyp2g1 / 25251	RGDID:	2477	Length:	494	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	157/524 - (29%)
Similarity:	256/524 - (48%)	Gaps:	63/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSD 69
            ||:...|...:|........|....||||..:|:|||.||.|.:|:               |:|
  Rat     9 IFMTLCLSCLLILIAWKRTSRGGKLPPGPTPIPFLGNLLQVRIDAT---------------FQS- 57

  Fly    70 LVGLKLGREY------------VVVALGHEMVKEVQLQEV--FEGRPDNFFLRLRTMGTRKGITC 120
              .|||.::|            ||:..|||.|||..:.:.  |.||.:...|.....|  .|:..
  Rat    58 --FLKLQKKYGSVFTVYFGPRPVVILCGHEAVKEALVDQADDFSGRGEMPTLEKNFQG--YGLAL 118

  Fly   121 TDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLW 185
            ::|:.|...|.|::..:||.|.|:..:|..|:.||..||.:|.:.:..||:|..:|:::|.||:.
  Rat   119 SNGERWKILRRFSLTVLRNFGMGKRSIEERIQEEAGYLLEELHKVKGAPIDPTFYLSRTVSNVIC 183

  Fly   186 CLIAGKRIARQEDGTLRRLLDLMNRR--------SKLFDICGGLLAQFPWLRHVAPDRTGYNLIQ 242
            .::.|||. ..||...|.|:.::|..        ::|:|:..|::..||. ||   :|. ||||:
  Rat   184 SVVFGKRF-DYEDQRFRSLMKMINESFVEMSMPWAQLYDMYWGVIQYFPG-RH---NRL-YNLIE 242

  Fly   243 QLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEM-KDRSAGGESSTFNETQLVMTILDF 306
                ||..|....::.:  :.:.|||... |.|..:|.:| :|:|  ...|.||...||:|.|:.
  Rat   243 ----ELKDFIASRVKIN--EASFDPSNPR-DFIDCFLIKMYQDKS--DPHSEFNLKNLVLTTLNL 298

  Fly   307 FIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQ 371
            |.||::|.|:|:....::|...|:|:.|:..::...:....|   |.:..|....|.||.|.|:|
  Rat   299 FFAGTETVSSTLRYGFLLLMKYPEVEAKIHEEINQVIGTHRT---PRVDDRAKMPYTDAVIHEIQ 360

  Fly   372 RFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK 436
            |...|.|:..|...:..|...||.:||...:...:.||..|.::::.|..|.|:.|:|..|:..|
  Rat   361 RLTDIVPLGVPHNVIRDTHFRGYFLPKGTDVYPLIGSVLKDPKYFRYPEAFYPQHFLDEQGRFKK 425

  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLTPKPYKVQ 499
            ::.|:.|..|:|.|:|:||||..:|.:...|:|.||:  ::|..:......:.|....|..|::.
  Rat   426 NDAFVAFSSGKRICVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPTYELC 490

  Fly   500 FVKR 503
            |:.|
  Rat   491 FMAR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	150/494 (30%)
Cyp2g1	NP_036919.1	p450	34..491	CDD:278495	150/494 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920