DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c12

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_113760.2	Gene:	Cyp2c12 / 25011	RGDID:	2470	Length:	490	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	130/485 - (26%)
Similarity:	214/485 - (44%)	Gaps:	53/485 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILIGFVIYSLISSARRPK----NFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSDL 70
            :|:..:.:.|:....||.    ..||||..:|..||.||..                .||.|..:
  Rat     6 VLVLSLSFLLLLYLWRPSPGRGKLPPGPTPLPIFGNFLQID----------------MKDIRQSI 54

  Fly    71 VG----------LKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDG 123
            ..          |..|.:..||..|:|.|||  :...|.|.||.........|.|.  ||:.:.|
  Rat    55 SNFSKTYGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKGL--GISFSRG 117

  Fly   124 QLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLI 188
            .:|...|||.:..:|::|.|:..:|..::.|||.|:.:|::|:..|.:|...:..:..||:..:|
  Rat   118 NVWRATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICSII 182

  Fly   189 AGKRIARQEDGTLRRLLDLMNRRSKL-----FDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTEL 248
            ...|. ..:|.....|::.:|...|:     |.:...    ||.|....|.  .:....:....:
  Rat   183 FQNRF-DYKDKDFLSLIENVNEYIKIVSTPAFQVFNA----FPILLDYCPG--NHKTHSKHFAAI 240

  Fly   249 YGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQT 313
            ..:.:..|:||...|  |.|.....:.|..:|..::.  |.:...:.:..|.:.:.:.||.|::|
  Rat   241 KSYLLKKIKEHEESL--DVSNPRDFIDYFLIQRCQEN--GNQQMNYTQEHLAILVTNLFIGGTET 301

  Fly   314 TSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITP 378
            :|.|:..||::|...|.:.:|:..::...:....:   |.:..|....|.:|.|.||||:..:.|
  Rat   302 SSLTLRFALLLLMKYPHITDKVQEEIGQVIGRHRS---PCMLDRIHMPYTNAMIHEVQRYIDLAP 363

  Fly   379 ITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPF 443
            ..........||...|.|||...:|.||.||..|.:.:.:|..|.|..|:|..|...|.:|||||
  Rat   364 NGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFMPF 428

  Fly   444 GMGRRRCLGDALARACIFSFLVRIVQHFSV 473
            ..|:|:|:|:.||...:|.||..|:|:|.:
  Rat   429 SAGKRKCVGEGLASMELFLFLTTILQNFKL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	126/461 (27%)
Cyp2c12	NP_113760.2	CYP2C-like	61..485	CDD:410758	114/414 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010