DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2a3

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_036674.1	Gene:	Cyp2a3 / 24299	RGDID:	2465	Length:	494	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	140/515 - (27%)
Similarity:	233/515 - (45%)	Gaps:	43/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRS 68
            |:...|.|...|:.|:....:.....||||..:|::||.||...| ........:.:|:...|.
  Rat     8 LVASVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIGNYLQLNTE-KMYSSLMKISQRYGPVFT- 70

  Fly    69 DLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRH 131
                :.||...|||..|.|.|||  |...|.|.||.:.........|  .|:..:.|:...:.|.
  Rat    71 ----IHLGPRRVVVLCGQEAVKEALVDQAEEFSGRGEQATFDWLFKG--YGVAFSSGERAKQLRR 129

  Fly   132 FAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQ 196
            |::..:|:.|.|:..:|..|:.||..|:....:|....|:|..:|:::|.||:..::.|.|. ..
  Rat   130 FSIATLRDFGVGKRGIEERIQEEAGFLIESFRKTNGALIDPTFYLSRTVSNVISSIVFGDRF-DY 193

  Fly   197 EDGTLRRLLDLM--------NRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGFFM 253
            ||.....||.:|        ....:|:::...::...|     .|.:..:..:|.|.    .|..
  Rat   194 EDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLP-----GPQQQAFKELQGLE----DFIT 249

  Fly   254 DTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTI 318
            ..:|:::|.|  ||: :..|.|.::|..|.:... ..::.|....||:|.|:.|.||::|.|.|:
  Rat   250 KKVEQNQRTL--DPN-SPRDFIDSFLIRMLEEKK-NPNTEFYMKNLVLTTLNLFFAGTETVSTTL 310

  Fly   319 NLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPR 383
            ....::|...||::.|:..::...:.......:   ..|....|.:|.|.|:|||..:.|:...|
  Rat   311 RYGFLLLMKHPDIEAKVHEEIDRVIGRNRQAKY---EDRMKMPYTEAVIHEIQRFADMIPMGLAR 372

  Fly   384 RALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRR 448
            |....||...:.:||...:...|.||..|.:.:.:|.:|.|:.|:|..|:..|.:.|:||.:|:|
  Rat   373 RVTKDTKFREFLLPKGTEVFPMLGSVLKDPKFFSNPNDFNPKHFLDDKGQFKKSDAFVPFSIGKR 437

  Fly   449 RCLGDALARACIFSFLVRIVQHFSVVLPAGE-----SPSMVLLPGITLTPKPYKVQFVKR 503
            .|.|:.|||..:|.||..|:|:|....|...     ||.:|   |....|..|.:.|:.|
  Rat   438 YCFGEGLARMELFLFLTNIMQNFCFKSPQAPQDIDVSPRLV---GFATIPPNYTMSFLSR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	133/484 (27%)
Cyp2a3	NP_036674.1	p450	34..491	CDD:278495	133/484 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920