DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2a22

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001094937.1	Gene:	Cyp2a22 / 233005	MGIID:	3648316	Length:	492	Species:	Mus musculus

Alignment Length:	529	Identity:	145/529 - (27%)
Similarity:	241/529 - (45%)	Gaps:	77/529 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRS 68
            |:.:.|.|...|:.|:.....|.| .||||..:|::||.||..:                ||..|
Mouse     8 LVAILAFLSVMVLVSVWQQKIRGK-LPPGPIPLPFIGNYLQLNR----------------KDVYS 55

  Fly    69 DLVGLK----------LGREYVVVALGHEMVKEV--QLQEVFEGRPDNFFLRLRTMGTRKGITCT 121
            .:..|:          ||...|||..|::.|||.  ...|.|.||.:.  ....|:....|:|.:
Mouse    56 SITQLQEHYGPVFTIHLGPRRVVVLYGYDAVKEALEDNAEEFSGRGEQ--ATFNTLFKGYGVTFS 118

  Fly   122 DGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWC 186
            :|:...:.|.|::..:::.|.|:..||..|:.||..|:..|:.|...||:|..:|:::|.||:..
Mouse   119 NGERAKQLRRFSIATLKDFGLGKRGMEERIQEEAGCLIKMLQGTCGAPIDPTMYLSKTVSNVISS 183

  Fly   187 LIAGKRIARQEDGTLRRLLDLMNRRS--------KLFDICGGLLAQFPWLRHVAPDRTGYNLIQQ 243
            ::.|.|. ..||.....||.:|::.:        :|:|:...::...|     .|.       ||
Mouse   184 IVFGDRF-NYEDKEFLSLLQMMSQMNQFAASPTGQLYDMFHSVMKYLP-----GPQ-------QQ 235

  Fly   244 L---NTELYGFFMDTIEEHRRQLAKDPSPAES--DLIYAYLQEMKDRSAGGESSTFNETQLVMTI 303
            :   :.:|..|.:..::.:...|  ||:....  |....::|:.|:     .:|.|:...||||.
Mouse   236 IIKDSHKLEDFMIQKVKHNHSTL--DPNSPRGFIDSFLIHMQKEKN-----FNSEFHMKNLVMTS 293

  Fly   304 LDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIM 368
            |:.|.|||:|.|:.:....::|...|||:.|:..::...:   ..:..|.........|..|.|.
Mouse   294 LNLFFAGSETVSSLLRYGFLLLMKHPDVEAKVHEEIDRVI---GRNRQPQYEDHMKMPYTQAVIH 355

  Fly   369 EVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGK 433
            |:|||.:..|:..|||....|...|:.:||...:...:.|:.:|.:.:..|.:|.|:.|:|..|:
Mouse   356 EIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTDVFPIMGSLMIDPKFFSSPKDFNPQHFLDDKGQ 420

  Fly   434 CFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLP-----AGESPSMVLLPGIT-LT 492
            ..|...|:||.:|:|.|||.:|.:..:|.|...|:|:|....|     ..|||..   .|.| :.
Mouse   421 LKKIPAFLPFSIGKRSCLGYSLGKMQLFLFFTTILQNFRFKFPRKLEDINESPKP---EGFTRII 482

  Fly   493 PKPYKVQFV 501
            || |.:.||
Mouse   483 PK-YTMSFV 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	136/500 (27%)
Cyp2a22	NP_001094937.1	p450	33..489	CDD:278495	136/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920