Protein Alignment Cyp305a1 and Cyp2a22

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001094937.1
• Gene: Cyp2a22 / 233005
• MGIID: 3648316
• Length: 492
• Species: Mus musculus
• Alignment Length: 529
• Identity: 145/529 - (27%)
• Similarity: 241/529 - (45%)
• Gaps: 77/529 - (14%)

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRS 68
            |:.:.|.|...|:.|:.....|.| .||||..:|::||.||..:                ||..|
Mouse     8 LVAILAFLSVMVLVSVWQQKIRGK-LPPGPIPLPFIGNYLQLNR----------------KDVYS 55

  Fly    69 DLVGLK----------LGREYVVVALGHEMVKEV--QLQEVFEGRPDNFFLRLRTMGTRKGITCT 121
            .:..|:          ||...|||..|::.|||.  ...|.|.||.:.  ....|:....|:|.:
Mouse    56 SITQLQEHYGPVFTIHLGPRRVVVLYGYDAVKEALEDNAEEFSGRGEQ--ATFNTLFKGYGVTFS 118

  Fly   122 DGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWC 186
            :|:...:.|.|::..:::.|.|:..||..|:.||..|:..|:.|...||:|..:|:::|.||:..
Mouse   119 NGERAKQLRRFSIATLKDFGLGKRGMEERIQEEAGCLIKMLQGTCGAPIDPTMYLSKTVSNVISS 183

  Fly   187 LIAGKRIARQEDGTLRRLLDLMNRRS--------KLFDICGGLLAQFPWLRHVAPDRTGYNLIQQ 243
            ::.|.|. ..||.....||.:|::.:        :|:|:...::...|     .|.       ||
Mouse   184 IVFGDRF-NYEDKEFLSLLQMMSQMNQFAASPTGQLYDMFHSVMKYLP-----GPQ-------QQ 235

  Fly   244 L---NTELYGFFMDTIEEHRRQLAKDPSPAES--DLIYAYLQEMKDRSAGGESSTFNETQLVMTI 303
            :   :.:|..|.:..::.:...|  ||:....  |....::|:.|:     .:|.|:...||||.
Mouse   236 IIKDSHKLEDFMIQKVKHNHSTL--DPNSPRGFIDSFLIHMQKEKN-----FNSEFHMKNLVMTS 293

  Fly   304 LDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIM 368
            |:.|.|||:|.|:.:....::|...|||:.|:..::...:   ..:..|.........|..|.|.
Mouse   294 LNLFFAGSETVSSLLRYGFLLLMKHPDVEAKVHEEIDRVI---GRNRQPQYEDHMKMPYTQAVIH 355

  Fly   369 EVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGK 433
            |:|||.:..|:..|||....|...|:.:||...:...:.|:.:|.:.:..|.:|.|:.|:|..|:
Mouse   356 EIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTDVFPIMGSLMIDPKFFSSPKDFNPQHFLDDKGQ 420

  Fly   434 CFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLP-----AGESPSMVLLPGIT-LT 492
            ..|...|:||.:|:|.|||.:|.:..:|.|...|:|:|....|     ..|||..   .|.| :.
Mouse   421 LKKIPAFLPFSIGKRSCLGYSLGKMQLFLFFTTILQNFRFKFPRKLEDINESPKP---EGFTRII 482

  Fly   493 PKPYKVQFV 501
            || |.:.||
Mouse   483 PK-YTMSFV 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	125/460 (27%)
Cyp2a22	NP_001094937.1	CYP2A	64..487	CDD:410761	123/451 (27%)