DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp305a1 and Cyp2c22

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_612521.2	Gene:	Cyp2c22 / 171518	RGDID:	620368	Length:	489	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	153/519 - (29%)
Similarity:	248/519 - (47%)	Gaps:	50/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFE--RWA 63
            |:..|||...|...|...|.:.....:..||||..:|..||.||       ||.::|...  ..|
  Rat     1 MALFIFLGIWLSCLVFLFLWNQHHVRRKLPPGPTPLPIFGNILQ-------VGVKNISKSMCMLA 58

  Fly    64 KDFRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGITCTDGQLW 126
            |:: ..:..:.||.:..||..|:|::||..:.  |.|..:..:..|...:.|.  ||..::|::|
  Rat    59 KEY-GPVFTMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSMLSKVSQGL--GIVFSNGEIW 120

  Fly   127 YEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGK 191
            .:.|.|::..:|::|.|:..:|:.|:.|...||..|.:|...|.:|...||....||:..:|...
  Rat   121 KQTRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALRKTNGSPCDPSFLLACVPCNVISSVIFQH 185

  Fly   192 RIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLN----------T 246
            |. ...|...::.::  |..:|:     .:||. ||    |...:.|.::..|.          |
  Rat   186 RF-DYSDEKFQKFIE--NFHTKI-----EILAS-PW----AQLCSAYPVLYYLPGIHNKFLKDVT 237

  Fly   247 ELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAG 310
            |...|.:..|..||..| ..:|    .|.|..:|.:| ::....|.|.|....|::||.|.|.||
  Rat   238 EQKKFILMEINRHRASLNLSNP----QDFIDYFLIKM-EKEKHNEKSEFTMDNLIVTIGDLFGAG 297

  Fly   311 SQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFH 375
            ::|||:||...|::|...|:|..|:..::|..:.....   |.:..|....|.||.:.|:||:..
  Rat   298 TETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHRR---PCMQDRNHMPYTDAVLHEIQRYID 359

  Fly   376 ITPITGPRRALWATKLGGYDIPKNATILISLRS-VHLDKEHWKDPLEFRPERFIDSAGKCFKDEY 439
            ..||..||:.....:..||.|||..:::..|.| :|.||| :.:|.:|.|..|:|..|...|.:|
  Rat   360 FVPIPLPRKTTQDVEFRGYHIPKGTSVMACLTSALHDDKE-FPNPEKFDPGHFLDEKGNFKKSDY 423

  Fly   440 FMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLTPKPYKVQFV 501
            ||.|..|||.|:|:.|||..:|..|..|:|||::  ::...:..:..:.||:...|.|:::.|:
  Rat   424 FMAFSAGRRACIGEGLARMEMFLILTSILQHFTLKPLVNPEDIDTTPVQPGLLSVPPPFELCFI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	145/487 (30%)
Cyp2c22	NP_612521.2	CYP2C-like	61..484	CDD:410758	131/447 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920