Protein Alignment Cyp305a1 and CYP2J2

DIOPT Version :9

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000766.2
• Gene: CYP2J2 / 1573
• HGNCID: 2634
• Length: 502
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 162/517 - (31%)
• Similarity: 269/517 - (52%)
• Gaps: 55/517 - (10%)

  Fly     3 ALIFLCAILIGFVIYSLIS---SARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAK 64
            |::....:|:|.|.:.|.:   ..|||||:||||..:|:|||......|.|     |:..:.:.|
Human    14 AVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQS-----HLEVQLFVK 73

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRP-----DNFFLRLRTMGTRKGITCTD 122
            .: .:|..|:||....|:..|..::||  :.:.:.|..||     ::.|       .:.|:..:.
Human    74 KY-GNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIF-------KKNGLIMSS 130

  Fly   123 GQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCL 187
            ||.|.|.|.|.:..:||.|.|:..:|..|:.||:.|...::....||.:|...:..:|.|::..:
Human   131 GQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSI 195

  Fly   188 IAGKRIARQEDGTLRRLLDLM--------NRRSKLFDICGGLLAQFPWLRHV--APDRTGYNLIQ 242
            ..|:|...| |...::||.|:        ::..:|:::       |||:...  .|.:|.::..:
Human   196 TFGERFEYQ-DSWFQQLLKLLDEVTYLEASKTCQLYNV-------FPWIMKFLPGPHQTLFSNWK 252

  Fly   243 QLNTELYGFFMDTIEEHRRQLAKDPSPAES-DLIYAYLQEMKDRSAGGESSTFNETQLVMTILDF 306
            :|..    |....|::||    ||.:|||: |.|.|||:|| .:..|..:|:|:|..|:.:.||.
Human   253 KLKL----FVSHMIDKHR----KDWNPAETRDFIDAYLKEM-SKHTGNPTSSFHEENLICSTLDL 308

  Fly   307 FIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQ 371
            |.||::|||.|:..||:.:|:.|::|||:.:::...:.....   |..:.||:..|.:|.|.|||
Human   309 FFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQ---PSTAARESMPYTNAVIHEVQ 370

  Fly   372 RFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK 436
            |..:|.|:..||.....|.|.||.:||...||.:|.::|.|...|..|..|.|:.|::: |:..|
Human   371 RMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLEN-GQFKK 434

  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKV 498
            .|.||||.:|:|.|||:.|||..:|.|...::|.|:...|..|..|:....|||::|..:::
Human   435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	152/487 (31%)
CYP2J2	NP_000766.2	p450	44..497	CDD:365848	152/487 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68091
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3462
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3475
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.900