DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp305a1 and CYP2D7

DIOPT Version :9

Sequence 1:NP_649151.1 Gene:Cyp305a1 / 40161 FlyBaseID:FBgn0036910 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_001335315.1 Gene:CYP2D7 / 1564 HGNCID:2624 Length:516 Species:Homo sapiens


Alignment Length:544 Identity:161/544 - (29%)
Similarity:245/544 - (45%) Gaps:71/544 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSALIFLCAILIGFVIYSLISSARRPK----NFPPGPRFVPWLGNTLQFRKEASAVGGQHI---- 57
            :.||:.|..|:..|::  |:....|.:    .:||||..:|.|||.|            |:    
Human     3 LEALVPLAMIVAIFLL--LVDLMHRHQRWAARYPPGPLPLPGLGNLL------------HVDFQN 53

  Fly    58 ---LFERWAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTR-K 116
               .|::..:.| .|:..|:|....|||..|...|:|..:.  |....||.....::...|.| :
Human    54 TPYCFDQLRRRF-GDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQ 117

  Fly   117 GITCTD-GQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSV 180
            |:..:. |..|.|.|.|::..:||:|.|:..:|..:..||..|.........:|..|...|.::|
Human   118 GVILSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAV 182

  Fly   181 LNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGL---LAQFPWLRHVAPDRTGYNL-- 240
            .||:..|..|:|. ..:|....|||||.....|  :..|.|   |...|.|.|: |...|..|  
Human   183 SNVIASLTCGRRF-EYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLPHI-PALAGKVLRF 243

  Fly   241 ----IQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVM 301
                :.||:        :.:.|||  :..||:....||..|:|.: |:::.|...|:||:..|.:
Human   244 QKAFLTQLD--------ELLTEHR--MTWDPAQPPRDLTEAFLAK-KEKAKGSPESSFNDENLRI 297

  Fly   302 TILDFFIAGSQTTSNTINLALMVLAMRPDVQE-KLFSQVTASVAAAST----------DAFPHLS 355
            .:.:.|:||..|||.|:...|:::.:..|||. :..|...:.:.....          |....:.
Human   298 VVGNLFLAGMVTTSTTLAWGLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRVQQEIDDVIGQVR 362

  Fly   356 RREAFDY-----MDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEH 415
            |.|..|.     ..|.|.|||.|..|.|:..........::.|:.|||..|::.:|.||..|:..
Human   363 RPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV 427

  Fly   416 WKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGE- 479
            ||.|..|.||.|:|:.|...|.|.|:||..|||.|||:.|||..:|.|...::||||..:.||: 
Human   428 WKKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQP 492

  Fly   480 SPSMVLLPGITLTPKPYKVQFVKR 503
            .||...:....:||.||::..|.|
Human   493 RPSHSRVVSFLVTPSPYELCAVPR 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp305a1NP_649151.1 p450 30..500 CDD:278495 152/506 (30%)
CYP2D7NP_001335315.1 p450 58..512 CDD:306555 142/469 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45226
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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