DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and CYP2C18

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000763.1	Gene:	CYP2C18 / 1562	HGNCID:	2620	Length:	490	Species:	Homo sapiens

Alignment Length:	514	Identity:	148/514 - (28%)
Similarity:	226/514 - (43%)	Gaps:	64/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |...:.|...|....:.||...:......|.||..:|.:||.||..                .||
Human     1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLD----------------VKD 49

  Fly    66 FRSDLVGLK----------LGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGI 118
            ....|....          .|.:.:||..|:|.|||..:.  |.|.||  ..|.....:....||
Human    50 MSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGR--GSFPVAEKVNKGLGI 112

  Fly   119 TCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNV 183
            ..::|:.|.|.|.|.:..:||.|.|:..:|..::.||..|:.:|.:|...|.:|...|..:..||
Human   113 LFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNV 177

  Fly   184 LWCLIAGKRIARQEDGTLRRLLDLMNR--------RSKLFDICGGLLAQFPWLRHVAPDRTGYNL 240
            :..:|...|...::    :|.|:||.:        .|....:|.    .||.|....|.  .:|.
Human   178 ICSVIFHDRFDYKD----QRFLNLMEKFNENLRILSSPWIQVCN----NFPALIDYLPG--SHNK 232

  Fly   241 IQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILD 305
            |.:....:..:.::.|:||:..|  |.:.|. |.|..:|.:| ::....:.|.|....|:.|:.|
Human   233 IAENFAYIKSYVLERIKEHQESL--DMNSAR-DFIDCFLIKM-EQEKHNQQSEFTVESLIATVTD 293

  Fly   306 FFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEV 370
            .|.||::|||.|:...|::|...|:|..|:..::...|   ..:..|.:..|....|.||.:.|:
Human   294 MFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV---GRNRSPCMQDRSHMPYTDAVVHEI 355

  Fly   371 QRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSV-HLDKEHWKDPLEFRPERFIDSAGKC 434
            ||:..:.|...|.......|...|.|||..||:.||.|| |.||| :.:|..|.|..|:|.:|..
Human   356 QRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKE-FPNPEMFDPGHFLDKSGNF 419

  Fly   435 FKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTP 493
            .|.:|||||..|:|.|:|:.|||..:|.||..|:|:|::       .|.|....|.:||
Human   420 KKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL-------KSQVDPKDIDITP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	143/485 (29%)
CYP2C18	NP_000763.1	p450	30..487	CDD:306555	143/485 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920