Protein Alignment Cyp305a1 and CYP2C9

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000762.2
• Gene: CYP2C9 / 1559
• HGNCID: 2623
• Length: 490
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 153/529 - (28%)
• Similarity: 241/529 - (45%)
• Gaps: 69/529 - (13%)

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |.:|:.|...|...::.||...:......||||..:|.:||.||       :|         .||
Human     1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQ-------IG---------IKD 49

  Fly    66 FRSDLVGLK----------LGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGI 118
            ....|..|.          .|.:.:||..|:|.|||  :.|.|.|.||  ..|..........||
Human    50 ISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR--GIFPLAERANRGFGI 112

  Fly   119 TCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNV 183
            ..::|:.|.|.|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||
Human   113 VFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

  Fly   184 LWCLIAGKRIARQEDGTLRRLLDLMNRRSKL-----FDICGG---LLAQFP-----WLRHVAPDR 235
            :..:|..||. ..:|.....|::.:|...|:     ..||..   ::..||     .|::||
Human   178 ICSIIFHKRF-DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA--- 238

  Fly   236 TGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLV 300
                       .:..:.::.::||:..:..: :|  .|.|..:|.:| ::....:.|.|....|.
Human   239 -----------FMKSYILEKVKEHQESMDMN-NP--QDFIDCFLMKM-EKEKHNQPSEFTIESLE 288

  Fly   301 MTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDA 365
            .|.:|.|.||::|||.|:..||::|...|:|..|:..::...:   ..:..|.:..|....|.||
Human   289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI---GRNRSPCMQDRSHMPYTDA 350

  Fly   366 FIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDS 430
            .:.||||:..:.|.:.|.......|...|.|||..||||||.||..|.:.:.:|..|.|..|:|.
Human   351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415

  Fly   431 AGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHF---SVVLPAGESPSMVLLPGITLT 492
            .|...|.:|||||..|:|.|:|:|||...:|.||..|:|:|   |:|.|.....:.| :.|....
Human   416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV-VNGFASV 479

  Fly   493 PKPYKVQFV 501
            |..|::.|:
Human   480 PPFYQLCFI 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	134/457 (29%)
CYP2C9	NP_000762.2	CYP2C-like	61..485	CDD:410758	132/448 (29%)