DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and CYP2C9

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000762.2	Gene:	CYP2C9 / 1559	HGNCID:	2623	Length:	490	Species:	Homo sapiens

Alignment Length:	529	Identity:	153/529 - (28%)
Similarity:	241/529 - (45%)	Gaps:	69/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |.:|:.|...|...::.||...:......||||..:|.:||.||       :|         .||
Human     1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQ-------IG---------IKD 49

  Fly    66 FRSDLVGLK----------LGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGI 118
            ....|..|.          .|.:.:||..|:|.|||  :.|.|.|.||  ..|..........||
Human    50 ISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR--GIFPLAERANRGFGI 112

  Fly   119 TCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNV 183
            ..::|:.|.|.|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||
Human   113 VFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

  Fly   184 LWCLIAGKRIARQEDGTLRRLLDLMNRRSKL-----FDICGG---LLAQFP-----WLRHVAPDR 235
            :..:|..||. ..:|.....|::.:|...|:     ..||..   ::..||     .|::||
Human   178 ICSIIFHKRF-DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA--- 238

  Fly   236 TGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLV 300
                       .:..:.::.::||:..:..: :|  .|.|..:|.:| ::....:.|.|....|.
Human   239 -----------FMKSYILEKVKEHQESMDMN-NP--QDFIDCFLMKM-EKEKHNQPSEFTIESLE 288

  Fly   301 MTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDA 365
            .|.:|.|.||::|||.|:..||::|...|:|..|:..::...:   ..:..|.:..|....|.||
Human   289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI---GRNRSPCMQDRSHMPYTDA 350

  Fly   366 FIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDS 430
            .:.||||:..:.|.:.|.......|...|.|||..||||||.||..|.:.:.:|..|.|..|:|.
Human   351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415

  Fly   431 AGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHF---SVVLPAGESPSMVLLPGITLT 492
            .|...|.:|||||..|:|.|:|:|||...:|.||..|:|:|   |:|.|.....:.| :.|....
Human   416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV-VNGFASV 479

  Fly   493 PKPYKVQFV 501
            |..|::.|:
Human   480 PPFYQLCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	146/497 (29%)
CYP2C9	NP_000762.2	p450	30..487	CDD:306555	146/497 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920